Isolation of Bokeloh bat lyssavirus in Myotis nattereri in France

Isolation of Bokeloh bat lyssavirus in Myotis nattereri in France Bokeloh bat lyssavirus (BBLV) was found in Myotis nattereri for the first time in northeastern France in July 2012. The complete genome sequence of the virus from the infected Natterer’s bat was determined by whole-genome sequencing and compared to that of the first BBLV strain isolated in 2010 in Germany and with those of all currently identified lyssaviruses. The French isolate (KC169985) showed 98.7 % nucleotide sequence identity to the German BBLV strain (JF311903). Several organs of the infected French bat were examined by classical rabies diagnostic methods: fluorescent antibody test, cell culture inoculation test and RT-qPCR. Antigen, infectious virus and high viral RNA levels were found in both the brain and salivary glands. Traces of genomic RNA were detected in the bladder, kidney and lung tissue. The results of an investigation of the distribution of lyssaviruses with the detection of infectious virus in the salivary glands suggest a possible mode of transmission of the virus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Isolation of Bokeloh bat lyssavirus in Myotis nattereri in France

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1747-y
Publisher site
See Article on Publisher Site

Abstract

Bokeloh bat lyssavirus (BBLV) was found in Myotis nattereri for the first time in northeastern France in July 2012. The complete genome sequence of the virus from the infected Natterer’s bat was determined by whole-genome sequencing and compared to that of the first BBLV strain isolated in 2010 in Germany and with those of all currently identified lyssaviruses. The French isolate (KC169985) showed 98.7 % nucleotide sequence identity to the German BBLV strain (JF311903). Several organs of the infected French bat were examined by classical rabies diagnostic methods: fluorescent antibody test, cell culture inoculation test and RT-qPCR. Antigen, infectious virus and high viral RNA levels were found in both the brain and salivary glands. Traces of genomic RNA were detected in the bladder, kidney and lung tissue. The results of an investigation of the distribution of lyssaviruses with the detection of infectious virus in the salivary glands suggest a possible mode of transmission of the virus.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 2013

References

  • Rabies virus distribution in tissues and molecular characterization of strains from naturally infected non-hematophagous bats
    Allendorf, SD; Cortez, A; Heinemann, MB; Harary, CM; Antunes, JM; Peres, MG; Vicente, AF; Sodre, MM; Rosa, AR; Megid, J

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