Ischemic stroke and select adipose-derived and sex hormones: a review

Ischemic stroke and select adipose-derived and sex hormones: a review Ischemic stroke is the fifth leading cause of death in the USA and is the leading cause of serious, long-term disability worldwide. The principle sex hormones (estrogen, progesterone, and testosterone), both endogenous and exogenous, have profound effects on various stroke outcomes and have become the focus of a number of studies evaluating risk factors and treatment options for ischemic stroke. In addition, the expression of other hormones that may influence stroke outcome, including select adipose- derived hormones (adiponectin, leptin, and ghrelin), can be regulated by sex hormones and are also the focus of several ischemic stroke studies. This review aims to summarize some of the preclinical and clinical studies investigating the principle sex hormones, as well as select adipose-derived hormones, as risk factors or potential treatments for ischemic stroke. In addition, the potential for relaxin, a lesser studied sex hormone, as a novel treatment option for ischemic stroke is explored. . . . . . . Keywords Ischemic stroke Sex hormones Relaxin Adipose-derived hormones Adiponectin Leptin Ghrelin Introduction preclinical and clinical studies investigating the principle sex hormones, as well as select adipose-derived hormones, as risk Stroke is the fifth leading cause of death in the USA behind factors or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hormones Springer Journals

Ischemic stroke and select adipose-derived and sex hormones: a review

Hormones , Volume OnlineFirst – Jun 6, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Hellenic Endocrine Society
Subject
Medicine & Public Health; Medicine/Public Health, general; Endocrinology; Metabolic Diseases
ISSN
1109-3099
eISSN
2520-8721
D.O.I.
10.1007/s42000-018-0034-4
Publisher site
See Article on Publisher Site

Abstract

Ischemic stroke is the fifth leading cause of death in the USA and is the leading cause of serious, long-term disability worldwide. The principle sex hormones (estrogen, progesterone, and testosterone), both endogenous and exogenous, have profound effects on various stroke outcomes and have become the focus of a number of studies evaluating risk factors and treatment options for ischemic stroke. In addition, the expression of other hormones that may influence stroke outcome, including select adipose- derived hormones (adiponectin, leptin, and ghrelin), can be regulated by sex hormones and are also the focus of several ischemic stroke studies. This review aims to summarize some of the preclinical and clinical studies investigating the principle sex hormones, as well as select adipose-derived hormones, as risk factors or potential treatments for ischemic stroke. In addition, the potential for relaxin, a lesser studied sex hormone, as a novel treatment option for ischemic stroke is explored. . . . . . . Keywords Ischemic stroke Sex hormones Relaxin Adipose-derived hormones Adiponectin Leptin Ghrelin Introduction preclinical and clinical studies investigating the principle sex hormones, as well as select adipose-derived hormones, as risk Stroke is the fifth leading cause of death in the USA behind factors or

Journal

HormonesSpringer Journals

Published: Jun 6, 2018

References

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