Arch Gynecol Obstet (2017) 296:495–502 DOI 10.1007/s00404-017-4461-2 MATERNAL-FETAL MEDICINE Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia? 1 1 2 1 Zeynep B. Güngör · Hakan Ekmekçi · Abdullah Tüten · Sait Toprak · 3 1 1 2 1 Gülsel Ayaz · Oktay Çalışkan · Hüseyin Sönmez · Rıza Madazlı · Orkide Donma · 1 3 1 Mine Kucur · Turgut Ulutin · Özlem Balcı Ekmekçi Received: 28 February 2017 / Accepted: 10 July 2017 / Published online: 13 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract compared to healthy pregnants. Endoglin also correlated Purpose Preeclampsia is a multisystem disorder and its with sflt-1 in preeclamptic patients. etiology remains still unclear. Recent hypotheses rely on Conclusion Increase in the levels of antiangiogenic fac- imbalance between angiogenic and antiangiogenic factors tors and leptin herewith decline in the level of other angio- and disruption of endothelial function of spiral arteries. genic factor PlGF, did not affect nitric oxide and platelet In addition; increased VTE (venous thromboembolism) aggregation markers significantly. Increased levels of vWF risk is still unclear in preeclampsia. Our aim was to inves- and endoglin might be result of endothelial dysfunction, tigate the relationship between endothelial dysfunction, so our findings suggest that an impaired angiogenesis may
Archives of Gynecology and Obstetrics – Springer Journals
Published: Jul 13, 2017
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