Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia?

Is there any relationship between adipocytokines and angiogenesis factors to address endothelial... Arch Gynecol Obstet (2017) 296:495–502 DOI 10.1007/s00404-017-4461-2 MATERNAL-FETAL MEDICINE Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia? 1 1 2 1 Zeynep B. Güngör  · Hakan Ekmekçi  · Abdullah Tüten  · Sait Toprak  · 3 1 1 2 1 Gülsel Ayaz  · Oktay Çalışkan  · Hüseyin Sönmez  · Rıza Madazlı  · Orkide Donma  · 1 3 1 Mine Kucur  · Turgut Ulutin  · Özlem Balcı Ekmekçi   Received: 28 February 2017 / Accepted: 10 July 2017 / Published online: 13 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract compared to healthy pregnants. Endoglin also correlated Purpose Preeclampsia is a multisystem disorder and its with sflt-1 in preeclamptic patients. etiology remains still unclear. Recent hypotheses rely on Conclusion Increase in the levels of antiangiogenic fac- imbalance between angiogenic and antiangiogenic factors tors and leptin herewith decline in the level of other angio- and disruption of endothelial function of spiral arteries. genic factor PlGF, did not affect nitric oxide and platelet In addition; increased VTE (venous thromboembolism) aggregation markers significantly. Increased levels of vWF risk is still unclear in preeclampsia. Our aim was to inves- and endoglin might be result of endothelial dysfunction, tigate the relationship between endothelial dysfunction, so our findings suggest that an impaired angiogenesis may http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Gynecology and Obstetrics Springer Journals

Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia?

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Gynecology; Obstetrics/Perinatology/Midwifery; Endocrinology; Human Genetics
ISSN
0932-0067
eISSN
1432-0711
D.O.I.
10.1007/s00404-017-4461-2
Publisher site
See Article on Publisher Site

Abstract

Arch Gynecol Obstet (2017) 296:495–502 DOI 10.1007/s00404-017-4461-2 MATERNAL-FETAL MEDICINE Is there any relationship between adipocytokines and angiogenesis factors to address endothelial dysfunction and platelet aggregation in untreated patients with preeclampsia? 1 1 2 1 Zeynep B. Güngör  · Hakan Ekmekçi  · Abdullah Tüten  · Sait Toprak  · 3 1 1 2 1 Gülsel Ayaz  · Oktay Çalışkan  · Hüseyin Sönmez  · Rıza Madazlı  · Orkide Donma  · 1 3 1 Mine Kucur  · Turgut Ulutin  · Özlem Balcı Ekmekçi   Received: 28 February 2017 / Accepted: 10 July 2017 / Published online: 13 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract compared to healthy pregnants. Endoglin also correlated Purpose Preeclampsia is a multisystem disorder and its with sflt-1 in preeclamptic patients. etiology remains still unclear. Recent hypotheses rely on Conclusion Increase in the levels of antiangiogenic fac- imbalance between angiogenic and antiangiogenic factors tors and leptin herewith decline in the level of other angio- and disruption of endothelial function of spiral arteries. genic factor PlGF, did not affect nitric oxide and platelet In addition; increased VTE (venous thromboembolism) aggregation markers significantly. Increased levels of vWF risk is still unclear in preeclampsia. Our aim was to inves- and endoglin might be result of endothelial dysfunction, tigate the relationship between endothelial dysfunction, so our findings suggest that an impaired angiogenesis may

Journal

Archives of Gynecology and ObstetricsSpringer Journals

Published: Jul 13, 2017

References

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