Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models

Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in... Pharm Res (2018) 35: 128 https://doi.org/10.1007/s11095-018-2413-6 RESEARCH PAPER Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models 1,2 1 3 4 4,5,6,7 Woan-Ruoh Lee & Shing-Chuan Shen & Calvin T. Sung & Pei-Ying Liu & Jia-You Fang Received: 12 February 2018 /Accepted: 18 April 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT of Er:glass modality did not further raise the flux via the SC- Purpose Most of the investigations into laser-assisted skin per- stripped skin. A similar trend was observed in the case of meation have used the intact skin as the permeation barrier. psoriasiform skin. Conversely, the flux was enhanced 3.7 Whether the laser is effective in improving cutaneous delivery and 2.6 fold after treatment with the Er:YAG and the via barrier-defective skin is still unclear. Er:glass laser on the atopic dermatitis (AD)-like skin. The 3- Methods In this study, ablative (Er:YAG) and non-ablative D skin structure captured by confocal microscopy proved the (Er:glass) lasers were examined for the penetration of peptide distribution of peptide and siRNA through the microchannels and siRNA upon topical application on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2413-6
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 128 https://doi.org/10.1007/s11095-018-2413-6 RESEARCH PAPER Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models 1,2 1 3 4 4,5,6,7 Woan-Ruoh Lee & Shing-Chuan Shen & Calvin T. Sung & Pei-Ying Liu & Jia-You Fang Received: 12 February 2018 /Accepted: 18 April 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT of Er:glass modality did not further raise the flux via the SC- Purpose Most of the investigations into laser-assisted skin per- stripped skin. A similar trend was observed in the case of meation have used the intact skin as the permeation barrier. psoriasiform skin. Conversely, the flux was enhanced 3.7 Whether the laser is effective in improving cutaneous delivery and 2.6 fold after treatment with the Er:YAG and the via barrier-defective skin is still unclear. Er:glass laser on the atopic dermatitis (AD)-like skin. The 3- Methods In this study, ablative (Er:YAG) and non-ablative D skin structure captured by confocal microscopy proved the (Er:glass) lasers were examined for the penetration of peptide distribution of peptide and siRNA through the microchannels and siRNA upon topical application on

Journal

Pharmaceutical ResearchSpringer Journals

Published: Apr 26, 2018

References

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