Pharm Res (2018) 35: 128 https://doi.org/10.1007/s11095-018-2413-6 RESEARCH PAPER Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models 1,2 1 3 4 4,5,6,7 Woan-Ruoh Lee & Shing-Chuan Shen & Calvin T. Sung & Pei-Ying Liu & Jia-You Fang Received: 12 February 2018 /Accepted: 18 April 2018 /Published online: 26 April 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT of Er:glass modality did not further raise the flux via the SC- Purpose Most of the investigations into laser-assisted skin per- stripped skin. A similar trend was observed in the case of meation have used the intact skin as the permeation barrier. psoriasiform skin. Conversely, the flux was enhanced 3.7 Whether the laser is effective in improving cutaneous delivery and 2.6 fold after treatment with the Er:YAG and the via barrier-defective skin is still unclear. Er:glass laser on the atopic dermatitis (AD)-like skin. The 3- Methods In this study, ablative (Er:YAG) and non-ablative D skin structure captured by confocal microscopy proved the (Er:glass) lasers were examined for the penetration of peptide distribution of peptide and siRNA through the microchannels and siRNA upon topical application on
Pharmaceutical Research – Springer Journals
Published: Apr 26, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera