Osteoporos Int (2017) 28:2611–2617 DOI 10.1007/s00198-017-4077-1 ORIGINAL ARTICLE Is the association between hip fractures and seasonality modified by influenza vaccination? An ecological study 1,2 2,3 3 2,4 M. Fraenkel & M. Yitshak-Sade & L. Beacher & M. Carmeli & 5,6 7 2,3 M. Mandelboim & E. Siris & V. Novack Received: 18 December 2016 /Accepted: 3 May 2017 /Published online: 23 May 2017 International Osteoporosis Foundation and National Osteoporosis Foundation 2017 Abstract diagnosis of osteoporotic hip fracture (ICD-9 code 820) be- Summary Osteoporotic hip fractures in 4344 patients were tween the years 2001 and 2013. Patients with malignancies, more common during winter. Lower temperatures were asso- trauma, and age under 50 were excluded. In a time series ciated with higher rates of fracture only in those not vaccinated analysis, we examined the association between hip fracture for influenza. Influenza outbreaks increased the risk of hip incidence and seasonality adjusted for meteorological factors, fractures. Further studies are needed to assess whether influ- and population rates of influenza infection and vaccination enza vaccination can prevent hip fractures. using Poisson models. Introduction Winter seasonality of osteoporotic hip fracture Results Four thousand three hundred forty-four patients with incidence has been demonstrated, yet the
Osteoporosis International – Springer Journals
Published: May 23, 2017
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