Is Microbiota Making You Fat? From Microbiota and Immune System to Obesity and Disease

Is Microbiota Making You Fat? From Microbiota and Immune System to Obesity and Disease Curr Trop Med Rep (2017) 4:146–152 DOI 10.1007/s40475-017-0112-8 NUTRITION (K SCHLOSSER MONTES, SECTION EDITOR) Is Microbiota Making You Fat? From Microbiota and Immune System to Obesity and Disease 1 2 María Antonieta Tuna & José Roberto Salazar Published online: 1 July 2017 Springer International Publishing AG 2017 Abstract Abbreviations Purpose of Review The aim of this review is to understand PCR Polymerase chain reaction how gut microbiota, immune system, and adipose tissue are SCFA Short-chain fatty acids involved in metabolic diseases. TNF Tumor necrosis factor Recent Findings Changes in the composition of gut micro- IL Interleukin biota have been related to obesity and metabolic diseases Treg Regulatory T cells pathogenesis. Gut microbiota antigens and metabolites go MALT Mucosa-associated lymphoid tissue through epithelial barriers and activate adipose, immune, GALT Gut-associated lymphoid tissue and epithelial cells. Activated cells produce chemical me- PRR Pathogen recognition receptors diators of inflammation and a mild, chronic, and sterile TLR Toll-like receptors inflammatory response. Inflammatory mediators promote NLRP NOD-like receptors insulin resistance and type 2 diabetes. RIG Retinoic acid inducible gen 1 receptor Summary In this document, we go over the factors that IFN Interferon affect the composition of gut microbiota, and how the DM Diabetes Current Tropical Medicine Reports Springer Journals

Is Microbiota Making You Fat? From Microbiota and Immune System to Obesity and Disease

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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG
Medicine & Public Health; Tropical Medicine; Parasitology; Behavioral Sciences; Infectious Diseases
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