Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Irwin, M. Grossman, D. Weintraub, H. Hurtig, J. Duda, S. Xie, Eddie Lee, V. Deerlin, O. Lopez, J. Kofler, P. Nelson, G. Jicha, R. Woltjer, J. Quinn, J. Quinn, J. Kaye, J. Leverenz, J. Leverenz, D. Tsuang, Katelan Longfellow, D. Yearout, W. Kukull, C. Keene, T. Montine, T. Montine, C. Zabetian, J. Trojanowski (2017)
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysisThe Lancet Neurology, 16
L. Volpicelli-Daley, Kelvin Luk, Tapan Patel, Selcuk Tanik, Dawn Riddle, Anna Stieber, D. Meaney, J. Trojanowski, V. Lee (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron DeathNeuron, 72
H. Braak, K. Tredici, U. Rüb, R. Vos, Ernst Steur, E. Braak (2003)
Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 24
K. Spinelli, JonathanK Taylor, Valerie Osterberg, M. Churchill, Eden Pollock, C. Moore, C. Meshul, Vivek Unni (2014)
Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's DiseaseThe Journal of Neuroscience, 34
C. Raiss, T. Braun, I. Konings, H. Grabmayr, Gerco Hassink, A. Sidhu, J. Feber, A. Bausch, C. Jansen, V. Subramaniam, M. Claessens (2016)
Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathologyScientific Reports, 6
Kelvin Luk, Victoria Kehm, J. Carroll, Bin Zhang, Patrick O’Brien, J. Trojanowski, V. Lee (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic MiceScience, 338
M. Spillantini, R., Anthony Crowther, R. Jakes, M. Hasegawa, M. Goedert (1998)
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodiesProceedings of the National Academy of Sciences of the United States of America, 95
G. Halliday, J. Holton, T. Révész, D. Dickson (2011)
Neuropathology underlying clinical variability in patients with synucleinopathiesActa Neuropathologica, 122
Valerie Osterberg, K. Spinelli, Leah Weston, Kelvin Luk, R. Woltjer, Vivek Unni (2015)
Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonismCell reports, 10
Markos Poulopoulos, O. Levy, R. Alcalay (2012)
The neuropathology of genetic Parkinson's diseaseMovement Disorders, 27
Paula Desplats, He‐Jin Lee, Eun-Jin Bae, C. Patrick, E. Rockenstein, L. Crews, B. Spencer, E. Masliah, Seung-Jae Lee (2009)
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synucleinProceedings of the National Academy of Sciences, 106
F. Lewy
Die Lehre vom Tonus und der Bewegung : Zugleich systematische Untersuchungen zur Klinik, Physiologie, Pathologie und Pathogenese der paralysis Agitans
D. Iacono, Maria Geraci-Erck, Marcie Rabin, C. Adler, G. Serrano, T. Beach, R. Kurlan (2015)
Parkinson disease and incidental Lewy body diseaseNeurology, 85
I. Alafuzoff, P. Ince, T. Arzberger, S. Al-Sarraj, J. Bell, I. Bodi, N. Bogdanovic, O. Bugiani, I. Ferrer, E. Gelpí, S. Gentleman, G. Giaccone, J. Ironside, N. Kavantzas, A. King, P. Korkolopoulou, G. Kovacs, D. Meyronet, C. Monoranu, Piero Parchi, L. Parkkinen, E. Patsouris, W. Roggendorf, A. Rozemuller, C. Stadelmann-nessler, N. Streichenberger, D. Thal, H. Kretzschmar (2009)
Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe ConsortiumActa Neuropathologica, 117
L Bousset, L Pieri, G Ruiz-Arlandis, J Gath, PH Jensen, B Habenstein, K Madiona, V Olieric, A Böckmann, BH Meier, R Melki (2013)
Structural and functional characterization of two alpha-synuclein strainsNat Commun, 4
DW Dickson, D Ruan, H Crystal, MH Mark, P Davies, Y Kress, SH Yen (1991)
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer’s disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBDNeurology, 41
H. Braak, D. Sandmann-Keil, W. Gai, E. Braak (1999)
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by α-synuclein immunocytochemistryNeuroscience Letters, 265
R. Melki (2018)
How the shapes of seeds can influence pathologyNeurobiology of Disease, 109
K. Tredici, H. Braak (2012)
Dysfunction of the locus coeruleus–norepinephrine system and related circuitry in Parkinson's disease-related dementiaJournal of Neurology, Neurosurgery & Psychiatry, 84
A. Villar-Piqué, Tomás Fonseca, Ricardo Sant’Anna, Éva Szegö, L. Fonseca-Ornelas, Raquel Pinho, Anita Čarija, E. Gerhardt, C. Masaracchia, Enrique Gonzalez, G. Rossetti, P. Carloni, C. Fernández, D. Foguel, Ira Milosevic, M. Zweckstetter, S. Ventura, T. Outeiro (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicityProceedings of the National Academy of Sciences, 113
J. Klucken, Anne-Maria Poehler, D. Ebrahimi‐Fakhari, J. Schneider, S. Nuber, E. Rockenstein, U. Schlötzer-Schrehardt, B. Hyman, P. McLean, E. Masliah, J. Winkler (2012)
Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathwayAutophagy, 8
T. Uchihara, B. Giasson (2015)
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studiesActa Neuropathologica, 131
(2003)
Cell Biol 12:9–14
E. Gómez-Tortosa, M. Irizarry, T. Gómez-Isla, B. Hyman (2000)
Clinical and Neuropathological Correlates of Dementia with Lewy BodiesAnnals of the New York Academy of Sciences, 920
W. Markesbery, G. Jicha, Huaichen Liu, F. Schmitt (2009)
Lewy Body Pathology in Normal Elderly SubjectsJournal of Neuropathology and Experimental Neurology, 68
Chunjuan Huang, Hanyang Cheng, Shu-feng Hao, Hui Zhou, Xujia Zhang, Jian-en Gao, Q. Sun, Hongyu Hu, Chih‐chen Wang (2006)
Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates.Journal of molecular biology, 364 3
F. Mori, K. Tanji, M. Yoshimoto, H. Takahashi, K. Wakabayashi (2002)
Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid PretreatmentExperimental Neurology, 176
D. Kaganovich, R. Kopito, J. Frydman (2008)
Misfolded proteins partition between two distinct quality control compartmentsNature, 454
D. Irwin, Matthew White, J. Toledo, S. Xie, John Robinson, V. Deerlin, V. Lee, J. Leverenz, T. Montine, J. Duda, H. Hurtig, J. Trojanowski (2012)
Neuropathologic substrates of Parkinson disease dementiaAnnals of Neurology, 72
E. Kuusisto, L. Parkkinen, I. Alafuzoff (2003)
Morphogenesis of Lewy Bodies: Dissimilar Incorporation of α‐Synuclein, Ubiquitin, and p62JNEN: Journal of Neuropathology & Experimental Neurology, 62
C. Zarow, S. Lyness, J. Mortimer, H. Chui (2003)
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases.Archives of neurology, 60 3
Samir Guglani (1890)
DeathThe Hospital, 8
P. Anglade, S. Vyas, E. Hirsch, Yves Agid (1997)
Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.Histology and histopathology, 12 3
L. Volpicelli-Daley, K. Gamble, Christine Schultheiss, Dawn Riddle, A. West, V. Lee (2014)
Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomesMolecular Biology of the Cell, 25
A. Harding, Emily Stimson, J. Henderson, G. Halliday (2002)
Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease.Brain : a journal of neurology, 125 Pt 11
Matthew Benskey, R. Perez, F. Manfredsson (2016)
The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's diseaseJournal of Neurochemistry, 137
I. Alafuzoff, P. Ince, T. Arzberger, S. Al-Sarraj, I. Bodi, N. Bogdanovic, E. Gelpí, P. Korkolopoulou, A. Rozemuller, H. Kretzschmar (2016)
Staging/typing of Lewy body related alpha-synuclein pathology
Yuko Saito, A. Kawashima, Nyoka Ruberu, Hideo Fujiwara, Shun‐ichi Koyama, M. Sawabe, T. Arai, H. Nagura, H. Yamanouchi, M. Hasegawa, T. Iwatsubo, S. Murayama (2003)
Accumulation of phosphorylated alpha-synuclein in aging human brain.Journal of neuropathology and experimental neurology, 62 6
L. Breydo, Jessica Wu, V. Uversky (2012)
Α-synuclein misfolding and Parkinson's disease.Biochimica et biophysica acta, 1822 2
V. Uversky (2017)
Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prismF1000Research, 6
Mohamed Fares, B. Maco, Abid Oueslati, E. Rockenstein, N. Ninkina, V. Buchman, E. Masliah, H. Lashuel (2016)
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s diseaseProceedings of the National Academy of Sciences, 113
H. Hurtig, J. Trojanowski, J. Galvin, D. Ewbank, M. Schmidt, V. Lee, C. Clark, G. Glosser, M. Stern, S. Gollomp, S. Arnold (2000)
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s diseaseNeurology, 54
J. Fearnley, A. Lees (1991)
Ageing and Parkinson's disease: substantia nigra regional selectivity.Brain : a journal of neurology, 114 ( Pt 5)
G. Respondek, C. Kurz, T. Arzberger, Y. Compta, E. Englund, L. Ferguson, E. Gelpí, A. Giese, D. Irwin, W. Meissner, C. Nilsson, A. Pantelyat, A. Rajput, J. Swieten, C. Troakes, K. Josephs, A. Lang, B. Mollenhauer, U. Müller, J. Whitwell, A. Antonini, K. Bhatia, Y. Bordelon, J. Corvol, C. Colosimo, R. Dodel, M. Grossman, J. Kassubek, F. Krismer, J. Levin, S. Lorenzl, H. Morris, P. Nestor, W. Oertel, G. Rabinovici, J. Rowe, T. Eimeren, G. Wenning, A. Boxer, L. Golbe, I. Litvan, M. Stamelou, G. Höglinger (2017)
Which ante mortem clinical features predict progressive supranuclear palsy pathology?Movement Disorders, 32
Masami Masuda-Suzukake, T. Nonaka, M. Hosokawa, Takayuki Oikawa, T. Arai, H. Akiyama, D. Mann, M. Hasegawa (2013)
Prion-like spreading of pathological α-synuclein in brainBrain, 136
J. Power, Olivia Barnes, F. Chegini (2017)
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy BodiesBrain Pathology, 27
A Shimozawa, M Ono, D Takahara, A Tarutani, S Imura, M Masuda-Suzukake, M Higuchi, K Yanai, SI Hisanaga, M Hasegawa (2017)
Propagation of pathological alpha-synuclein in marmoset brainActa Neuropathol Commun, 5
A. Lees, M. Selikhova, Luiz Andrade, C. Duyckaerts (2008)
The black stuff and Konstantin Nikolaevich TretiakoffMovement Disorders, 23
M. Irizarry, W. Growdon, T. Gómez-Isla, K. Newell, J. George, D. Clayton, B. Hyman (1998)
Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain α-synuclein ImmunoreactivityJournal of Neuropathology and Experimental Neurology, 57
H. Okazaki, L. Lipkin, S. Aronson (1961)
DIFFUSE INTRACYTOPLASMIC GANGLIONIC INCLUSIONS (LEWY TYPE) ASSOCIATED WITH PROGRESSIVE DEMENTIA AND QUADRIPARESIS IN FLEXIONJournal of Neuropathology and Experimental Neurology, 20
L. Parkkinen, S. O'sullivan, C. Collins, A. Petrie, J. Holton, T. Révész, A. Lees (2011)
Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.Journal of Parkinson's disease, 1 3
R. Youle, Derek Narendra (2010)
Mechanisms of mitophagyNature Reviews Molecular Cell Biology, 12
Jacqueline Burré (2015)
The Synaptic Function of α-SynucleinJournal of Parkinson's Disease, 5
C. Ruffmann, F. Calboli, I. Bravi, D. Gveric, L. Curry, A. Smith, S. Pavlou, J. Buxton, A. Blakemore, P. Takousis, S. Molloy, P. Piccini, D. Dexter, F. Roncaroli, S. Gentleman, L. Middleton (2016)
Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseasesNeuropathology and Applied Neurobiology, 42
Mikiei Tanaka, Yong Kim, Yong Kim, G. Lee, G. Lee, E. Junn, T. Iwatsubo, M. Mouradian (2004)
Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective*Journal of Biological Chemistry, 279
K. Doherty, L. Silveira-Moriyama, L. Parkkinen, D. Healy, M. Farrell, N. Mencacci, Z. Ahmed, F. Brett, J. Hardy, N. Quinn, T. Counihan, T. Lynch, Z. Fox, T. Révész, A. Lees, J. Holton (2013)
Parkin disease: a clinicopathologic entity?JAMA neurology, 70 5
Aki Shimozawa, M. Ono, Daisuke Takahara, A. Tarutani, Sei Imura, Masami Masuda-Suzukake, M. Higuchi, K. Yanai, S. Hisanaga, M. Hasegawa (2017)
Propagation of pathological α-synuclein in marmoset brainActa Neuropathologica Communications, 5
H. Braak, K. Tredici (2017)
Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the ChaffJournal of Parkinson's Disease, 7
C. Ross, Michelle Poirier (2005)
What is the role of protein aggregation in neurodegeneration?Nature Reviews Molecular Cell Biology, 6
M. Colom‐Cadena, Jordi Pegueroles, A. Herrmann, C. Henstridge, L. Muñoz, Marta Querol-Vilaseca, C. Martin, Joan Luque-Cabecerans, J. Clarimón, O. Belbin, Raúl Núñez-Llaves, R. Blesa, Colin Smith, Chris-Anne Mckenzie, M. Frosch, A. Roe, J. Fortea, J. Andilla, P. Loza-Álvarez, E. Gelpí, B. Hyman, Tara Spires-Jone, A. Lleó (2017)
Synaptic phosphorylated a-synuclein in dementia with Lewy bodies, 140
MD Zweig, ’. Jankel, MD Hedreen, MD Mayeux, MD”tf Price, Locust St, Reno (1989)
The pedunculopontine nucleus in Parkinson's diseaseAnnals of Neurology, 26
E. Freundt, Nate Maynard, Eileen Clancy, Shyamali Roy, Luc Bousset, Yannick Sourigues, M. Covert, R. Melki, K. Kirkegaard, M. Brahic (2012)
Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transportAnnals of Neurology, 72
L. Parkkinen, T. Kauppinen, T. Pirttilä, J. Autere, I. Alafuzoff (2005)
α‐Synuclein pathology does not predict extrapyramidal symptoms or dementiaAnnals of Neurology, 57
D. Calne, Y. Mizuno (2004)
The neuromythology of Parkinson's Disease.Parkinsonism & related disorders, 10 5
L. Maroteaux, JT Campanelli, R. Scheller (1988)
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal, 8
T. Kanazawa, E. Adachi, S. Orimo, A. Nakamura, H. Mizusawa, T. Uchihara (2012)
Pale Neurites, Premature α‐Synuclein Aggregates with Centripetal Extension from Axon CollateralsBrain Pathology, 22
K. Uryu, C. Richter-Landsberg, W. Welch, E. Sun, Olaf Goldbaum, E. Norris, Chi-Tuan Pham, I. Yazawa, Kristen Hilburger, Matthew Micsenyi, B. Giasson, N. Bonini, V. Lee, J. Trojanowski (2006)
Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-SynucleinopathiesAmerican Journal of Pathology, 168
K. Wakabayashi, K. Tanji, S. Odagiri, Y. Miki, F. Mori, H. Takahashi (2012)
The Lewy Body in Parkinson’s Disease and Related Neurodegenerative DisordersMolecular Neurobiology, 47
JA Johnston, CL Ward, RR Kopito (1998)
Aggresomes: a cellular response to misfolded proteinsJ Cell Sci, 143
Yuko Saito, A. Kawashima, Nyoka Ruberu, Hideo Fujiwara, Shun‐ichi Koyama, M. Sawabe, T. Arai, H. Yamanouchi, M. Hasegawa, T. Iwatsubo, S. Murayama (2003)
Accumulation of Phosphorylated α‐Synuclein in Aging Human BrainJNEN: Journal of Neuropathology & Experimental Neurology, 62
J Lowe, A Blanchard, K Morrell, G Lennox, L Reynolds, M Billett, M Landon, RJ Mayer (1988)
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson’s disease, Pick’s disease, and Alzheimer’s disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle and mallory bodies in alcoholic liver diseaseJ Pathol, 155
T. Kanazawa, T. Uchihara, Atsushi Takahashi, A. Nakamura, S. Orimo, H. Mizusawa (2008)
Three‐Layered Structure Shared Between Lewy Bodies and Lewy Neurites—Three‐Dimensional Reconstruction of Triple‐Labeled SectionsBrain Pathology, 18
K. Uryu, C. Richter-Landsberg, W. Welch, E. Sun, Olaf Goldbaum, E. Norris, Chi-Tuan Pham, I. Yazawa, Kristen Hilburger, Matthew Micsenyi, B. Giasson, N. Bonini, V. Lee, J. Trojanowski (2006)
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.The American journal of pathology, 168 3
IG McKeith, BF Boeve, DW Dickson, G Halliday, JP Taylor, D Weintraub, D Aarsland, J Galvin, J Attems, CG Ballard, A Bayston, TG Beach, F Blanc, N Bohnen, L Bonanni, J Bras, P Brundin, D Burn, A Chen-Plotkin, JE Duda, O El-Agnaf, H Feldman, TJ Ferman, D Ffytche, H Fujishiro, D Galasko, JG Goldman, SN Gomperts, NR Graff-Radford, LS Honig, A Iranzo, K Kantarci, D Kaufer, W Kukull, VMY Lee, JB Leverenz, S Lewis, C Lippa, A Lunde, M Masellis, E Masliah, P McLean, B Mollenhauer, TJ Montine, E Moreno, E Mori, M Murray, JT O'Brien, S Orimo, RB Postuma, S Ramaswamy, OA Ross, DP Salmon, A Singleton, A Taylor, A Thomas, P Tiraboschi, JB Toledo, JQ Trojanowski, D Tsuang, Z Walker, M Yamada, K Kosaka (2017)
Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortiumNeurology, 89
K. Jellinger (2015)
Neuropathobiology of non-motor symptoms in Parkinson diseaseJournal of Neural Transmission, 122
K. Kosaka (1978)
Lewy bodies in cerebral cortex. Report of three casesActa Neuropathologica, 42
Yvonne Eisele, C. Duyckaerts (2015)
Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studiesActa Neuropathologica, 131
S. Roy, L. Wolman (1969)
Ultrastructural observations in ParkinsonismThe Journal of Pathology, 99
J. Johnston, C. Ward, R. Kopito (1998)
Aggresomes: A Cellular Response to Misfolded ProteinsThe Journal of Cell Biology, 143
José Rodríguez, M. Ivanova, M. Sawaya, D. Cascio, F. Reyes, Dan Shi, S. Sangwan, E. Guenther, L. Johnson, Meng Zhang, Lin Jiang, M. Arbing, B. Nannenga, J. Hattne, J. Whitelegge, A. Brewster, M. Messerschmidt, S. Boutet, N. Sauter, T. Gonen, D. Eisenberg (2015)
Structure of the toxic core of α-synuclein from invisible crystalsNature, 525
B. Dehay, M. Martínez-Vicente, G. Caldwell, Kim Caldwell, Zhenyu Yue, Mark Cookson, C. Klein, M. Vila, E. Bézard (2013)
Lysosomal impairment in Parkinson's diseaseMovement Disorders, 28
O. Goker-Alpan, R. Schiffmann, M. Lamarca, R. Nussbaum, A. McInerney-Leo, E. Sidransky (2004)
Parkinsonism among Gaucher disease carriersJournal of Medical Genetics, 41
I. McKeith, B. Boeve, D. Dickson, G. Halliday, John-Paul Taylor, D. Weintraub, D. Aarsland, J. Galvin, J. Attems, C. Ballard, Ashley Bayston, T. Beach, F. Blanc, N. Bohnen, L. Bonanni, J. Bras, P. Brundin, D. Burn, A. Chen-Plotkin, J. Duda, O. El‐Agnaf, H. Feldman, T. Ferman, D. Ffytche, H. Fujishiro, D. Galasko, J. Goldman, S. Gomperts, N. Graff-Radford, L. Honig, Á. Iranzo, K. Kantarci, D. Kaufer, W. Kukull, V. Lee, J. Leverenz, S. Lewis, C. Lippa, A. Lunde, M. Masellis, E. Masliah, P. McLean, B. Mollenhauer, T. Montine, E. Moreno, E. Mori, Melissa Murray, J. O'Brien, Sotoshi Orimo, R. Postuma, S. Ramaswamy, O. Ross, D. Salmon, A. Singleton, Angela Taylor, Alan Thomas, P. Tiraboschi, J. Toledo, J. Trojanowski, D. Tsuang, Z. Walker, M. Yamada, K. Kosaka (2017)
Diagnosis and management of dementia with Lewy bodiesNeurology, 89
David Adamowicz, Subhojit Roy, D. Salmon, D. Galasko, L. Hansen, E. Masliah, F. Gage (2017)
Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of PathologyThe Journal of Neuroscience, 37
William Flavin, Luc Bousset, Z. Green, Y. Chu, Stratos Skarpathiotis, Michael Chaney, J. Kordower, R. Melki, E. Campbell (2017)
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteinsActa Neuropathologica, 134
Hideo Fujiwara, M. Hasegawa, N. Dohmae, A. Kawashima, E. Masliah, M. Goldberg, Jie Shen, K. Takio, T. Iwatsubo (2002)
α-Synuclein is phosphorylated in synucleinopathy lesionsNature Cell Biology, 4
K. Sano, Ryuichiro Atarashi, K. Satoh, D. Ishibashi, Takehiro Nakagaki, Y. Iwasaki, Mari Yoshida, S. Murayama, K. Mishima, N. Nishida (2017)
Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUICMolecular Neurobiology, 55
Gang Wang, Hai-lun Cui, Yue Huang (2018)
Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB ConsortiumNeurology, 90
W. Gai, P. Blumbergs, L. Geffen, W. Blessing (1992)
Age-related loss of dorsal vagal neurons in Parkinson's diseaseNeurology, 42
E. Kuusisto, A. Salminen, I. Alafuzoff (2001)
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathiesNeuroreport, 12
M Masuda-Suzukake, T Nonaka, M Hosokawa, T Oikawa, T Arai, H Akiyama, DM Mann, M Hasegawa (2013)
Prion-like spreading of pathological alpha-synuclein in brainBrain, 136
S. Paine, Glenn Anderson, Karen Bedford, K. Lawler, R. Mayer, J. Lowe, L. Bedford (2013)
Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-SynucleinPLoS ONE, 8
Eduard Bentea, Lise Verbruggen, A. Massie (2016)
The Proteasome Inhibition Model of Parkinson’s DiseaseJournal of Parkinson's Disease, 7
Laura Pieri, K. Madiona, Luc Bousset, R. Melki (2012)
Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells.Biophysical journal, 102 12
Hideo Fujiwara, M. Hasegawa, N. Dohmae, A. Kawashima, E. Masliah, M. Goldberg, Jie Shen, K. Takio, T. Iwatsubo (2002)
alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature cell biology, 4 2
R. Frigerio, H. Fujishiro, T. Ahn, K. Josephs, M. Demetrius, Maraganore, A. Delledonne, J. Parisi, K. Klos, B. Boeve, D. Dickson, Eric Ahlskog (2011)
Incidental Lewy body disease: Do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of Aging, 32
M. Sánchez-Guerra, L. Cerezal, C. Leno, C. Díez, J. Figols, J. Berciano (2001)
Primary brain lymphoma presenting as Parkinson's diseaseNeuroradiology, 43
K. Tredici, H. Braak (2012)
Lewy pathology and neurodegeneration in premotor Parkinson's diseaseMovement Disorders, 27
Mikiei Tanaka, Yong Kim, G. Lee, E. Junn, T. Iwatsubo, M. Mouradian (2004)
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.The Journal of biological chemistry, 279 6
J. Webb, B. Ravikumar, J. Atkins, J. Skepper, D. Rubinsztein (2003)
α-Synuclein Is Degraded by Both Autophagy and the Proteasome*Journal of Biological Chemistry, 278
F. Opazo, A. Krenz, S. Heermann, J. Schulz, B. Falkenburger (2008)
Accumulation and clearance of α‐synuclein aggregates demonstrated by time‐lapse imagingJournal of Neurochemistry, 106
N. Bengoa-Vergniory, Rosalind Roberts, R. Wade-Martins, J. Alegre-Abarrategui (2017)
Alpha-synuclein oligomers: a new hopeActa Neuropathologica, 134
Laura Pieri, K. Madiona, R. Melki (2016)
Structural and functional properties of prefibrillar α-synuclein oligomersScientific Reports, 6
S. Greffard, M. Verny, A. Bonnet, J. Beinis, C. Gallinari, S. Meaume, F. Piette, J. Hauw, C. Duyckaerts (2006)
Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra.Archives of neurology, 63 4
M. Polymeropoulos, C. Lavedan, E. Leroy, S. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W. Johnson, A. Lazzarini, R. Duvoisin, G. Iorio, L. Golbe, R. Nussbaum (1997)
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.Science, 276 5321
E. Braak, H. Braak (1999)
Silver staining method for demonstrating Lewy bodies in Parkinson’s disease and argyrophilic oligodendrocytes in multiple system atrophyJournal of Neuroscience Methods, 87
P. Box (2005)
α-synuclein pathology does not predict extrapyramidal symptoms or dementia
D Iacono, M Geraci-Erck, ML Rabin, CH Adler, G Serrano, TG Beach, R Kurlan (2015)
Parkinson disease and incidental Lewy body disease: just a question of time?Neurology, 85
Chuchu Wang, Chunyu Zhao, Dan Li, Zhiqi Tian, Y. Lai, Jiajie Diao, Cong Liu (2016)
Versatile Structures of α-SynucleinFrontiers in Molecular Neuroscience, 9
D. Dickson, H. Fujishiro, A. Delledonne, Joshua Menke, Z. Ahmed, K. Klos, K. Josephs, R. Frigerio, M. Burnett, J. Parisi, J. Ahlskog (2008)
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s diseaseActa Neuropathologica, 115
A. Samii, K. Markopoulou, Z. Wszolek, V. Sossi, T. Dobko, E. Mak, D. Calne, A. Stoessl (1999)
PET studies of parkinsonism associated with mutation in the alpha-synuclein gene.Neurology, 53 9
S. Abounit, Luc Bousset, F. Loria, Seng Zhu, F. Chaumont, Laura Pieri, Jean-Christophe Olivo-Marin, R. Melki, C. Zurzolo (2016)
Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomesThe EMBO Journal, 35
J. Tyedmers, A. Mogk, B. Bukau (2010)
Cellular strategies for controlling protein aggregationNature Reviews Molecular Cell Biology, 11
CA Ross, MA Poirier (2005)
Opinion: what is the role of protein aggregation in neurodegeneration?Nat Rev Mol Cell Biol, 6
D. Dickson, D. Ruan, H. Crystal, M. Mark, P. Davies, Y. Kress, S. Yen (1991)
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's diseaseNeurology, 41
(2011)
Trojanowki JQ, Lee VM (2011) Exogenous α
M. Colom‐Cadena, Jordi Pegueroles, A. Herrmann, C. Henstridge, L. Muñoz, Marta Querol-Vilaseca, Carla Martín-Paniello, Joan Luque-Cabecerans, J. Clarimón, O. Belbin, Raúl Núñez-Llaves, R. Blesa, Colin Smith, Chris-Anne Mckenzie, M. Frosch, A. Roe, J. Fortea, J. Andilla, P. Loza-Álvarez, E. Gelpí, B. Hyman, T. Spires-Jones, A. Lleó (2017)
Synaptic phosphorylated &agr;-synuclein in dementia with Lewy bodiesBrain, 140
M. Spillantini, R. Crowther, R. Jakes, M. Hasegawa, M. Goedert (1998)
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.Proceedings of the National Academy of Sciences of the United States of America, 95 11
Kunio Ii, Hidefumi Ito, A. Hirano (1997)
Immunocytochemical Co‐localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the ElderlyJournal of Neuropathology and Experimental Neurology, 56
S. Greffard, M. Verny, A. Bonnet, D. Seilhean, J. Hauw, C. Duyckaerts (2010)
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal deathNeurobiology of Aging, 31
Jada Lewis, D. Dickson (2015)
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studiesActa Neuropathologica, 131
M. Polymeropoulos, C. Lavedan, E. Leroy, S. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W. Johnson, A. Lazzarini, R. Duvoisin, G. Iorio, L. Golbe, R. Nussbaum (1997)
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 276
W. Peelaerts, Luc Bousset, A. Perren, A. Moskalyuk, Rocco Pulizzi, M. Giugliano, C. Haute, R. Melki, V. Baekelandt (2015)
α-Synuclein strains cause distinct synucleinopathies after local and systemic administrationNature, 522
Kelvin Luk, Cheng Song, Patrick O’Brien, Anna Stieber, Jonathan Branch, K. Brunden, J. Trojanowski, V. Lee (2009)
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cellsProceedings of the National Academy of Sciences, 106
K. McNaught, P. Jenner (2001)
Proteasomal function is impaired in substantia nigra in Parkinson's diseaseNeuroscience Letters, 297
Misfolded α-synuclein accumulates in histological inclusions constituting “Lewy pathology” found in idiopathic Parkinson disease, Parkinson disease dementia and dementia with Lewy body. The mechanism inducing α-synuclein misfolding is still unknown. The misfolded molecules form oligomers that organize into fibrils. α-Synuclein fibrils, in vitro, are capable of initiating an auto-replicating process, transforming normal molecules into misfolded molecules that aggregate. Fibrils can cross the neuronal membrane and recruit α-synuclein molecules in connected neurons. Such properties of seeding and propagation, shared with prion proteins, belong to “tissular propagons”. Lewy bodies isolate harmful species from the cytoplasm and have been thought to be protective. In PRKN gene mutations, however, the absence of Lewy bodies is not associated with a more aggressive course. In idiopathic Parkinson disease, the proportion of neurons with Lewy bodies in the substantia nigra remains stable despite the progression of neuronal loss. This stable proportion suggests that Lewy bodies are eliminated at the rate at which neurons are lost because Lewy bodies cause, or invariably accompany, neuronal loss. Experimentally, cellular death selectively occurs in inclusion-bearing neurons. This set of data indicates that α-synuclein misfolding is the essential mechanism causing the lesions of Parkinson disease and dementia with Lewy body. Lewy pathology is a direct and visible evidence of α-synuclein misfolding and, as such, is an accurate marker for assessing the presence of α-synuclein misfolding even if the inclusions themselves may not be as directly causative as the molecules they accumulate.
Cell and Tissue Research – Springer Journals
Published: Jun 5, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.