Between October 1999 and October 2003, S-100 serum protein concentration was measured in 880 samples obtained from 178 consecutive patients with histologically-confirmed malignant melanoma. S-100 concentration was measured with an assay based on three monoclonal antibodies against bovine S-100 protein B-subunit, using an automated chemiluminescence analyzer (Liaison, Diasorin, Saluggia, Italy). This method is much faster (less than 1 h) than the available technology which has been employed in most of previous studies in this field, and allows the surgeon to integrate S-100 concentration levels in his decision-making about patient management and follow-up scheduling. Seventeen out of 178 patients (9.55%) had local or distant metastasis. In 14 of them (82.35%), S-100 levels were higher then 250 ng/L (decision level) when disease progression was detected. Furthermore, the follow-up for five patients showed that a renewed rise of S-100 concentration reflected a new tumor recurrence. Our results confirm that serum S-100 concentration rises with disease progression, and that increased levels are often the first symptoms of recurrence. Furthermore, the study adds to this notion the clinical gain provided by availability of S-100 values before patient evaluation. The management of patients is greatly improved, with benefit to both patient and surgeon.
European Journal of Plastic Surgery – Springer Journals
Published: Aug 1, 2005
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera