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Leitthema Radiologe 2017 · 57:637–640 P. Wiggermann · K. Brünn · W. Bäumler DOI 10.1007/s00117-017-0251-x Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Regensburg, Deutschland Online publiziert: 5. Mai 2017 © Springer Medizin Verlag GmbH 2017 Eine minimal-invasive Methode zur Therapie des Prostatakarzinoms tion (IRE [20]), auf welche im Folgenden die nur in der MRT erkennbar sind, Prostatakarzinom näher eingegangen werden soll. erfolgen kann. Aufgrund des technisch- Das Prostatakarzinom ist aktuell der physikalischen Prinzips der IRE weist häufigste maligne Tumor des Mannes diese gegenüber alternativen thermi- Technisches Prinzip der IRE [10]. Obwohl die Zahlen der Todesfälle, schen Ablationsformen entscheidende die auf ein Prostatakarzinom zurück- Bei der IRE werden elektrische Hoch- Unterschiede auf. Erste Erfahrungen in zuführen sind, in den letzten Jahren spannungsimpulse (1500 V/cm, 70– der klinischen Anwendung zur mini- weitestgehend konstant geblieben sind, 90 Impulse in 70–90 s) abgegeben, die bei malinvasivenTumortherapiekonntenfür ist die Inzidenz dieser Erkrankung in ca. 50 Ampère in den Zellmembranen die IRE in den letzten Jahren gewonnen den letzten beiden Jahrzehnten deutlich kleine Poren (Ø 80–490 nm) erzeugen, werden. Neben der nichtthermischen gestiegen [15]. Diese Entwicklung er- welche es Molekülen ermöglichen, in Ablation von Lebermalignomen [8, 13] klärt sich v. a. durch den mittlerweile das Zielgewebe (Zellen)
Der Radiologe – Springer Journals
Published: May 5, 2017
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