Irinotecan/sorafenib

Irinotecan/sorafenib Reactions 1680, p194 - 2 Dec 2017 Diarrhoea: case report A 19-year-old man developed significant diarrhoea while receiving sorafenib and irinotecan for unresponsive renal masses [routes, dosages, duration of treatments to reaction onset and outcome not stated]. He subsequently died secondary to multisystem failure. The man was hospitalised because of a renal neoplasm. Following examinations, he underwent a radical tumour nephrectomy. After further examination, a diagnosis of TFE-3 translocation-associated renal cell carcinoma was made. He was initially treated with AREN0321 chemotherapy regimen for high risk renal tumours comprised cyclophosphamide, doxorubicin, vincristine and carboplatin, along with palliative radiation therapy but he developed disease progression. Consequently, the regimen was changed to COG protocol involving vincristine and irinotecan but no significant response was obtained. Hence, He started receiving a combination regimen of sorafenib and irinotecan which resulted in stable disease for nearly 8 weeks, but he experienced significant diarrhea. The man was advised to discontinue sorafenib and the treatment was changed to a combination of irinotecan, temsirolimus, and bevacizumab. Although, PET scan was negative, clinically progressive disease was developed under treatment and he died secondary to multisystem failure. Author comment: "It was decided to start the patient on a combination regimen consisting of Sorafenib plus Irinotecan. This combination resulted in stable disease for approximately 8 weeks. However, this combination caused significant diarrh[o]ea, and Sorafenib was stopped." Nelius T, et al. TFE3 translocation-associated renal cell carcinoma presenting as avascular necrosis of the femur in a 19-year-old patient: Case report and review of the literature. Case Reports in Medicine 2011: 14 Jul 2011. Available from: URL: http://doi.org/10.1155/2011/432917 - USA 803283898 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Irinotecan/sorafenib

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39125-7
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p194 - 2 Dec 2017 Diarrhoea: case report A 19-year-old man developed significant diarrhoea while receiving sorafenib and irinotecan for unresponsive renal masses [routes, dosages, duration of treatments to reaction onset and outcome not stated]. He subsequently died secondary to multisystem failure. The man was hospitalised because of a renal neoplasm. Following examinations, he underwent a radical tumour nephrectomy. After further examination, a diagnosis of TFE-3 translocation-associated renal cell carcinoma was made. He was initially treated with AREN0321 chemotherapy regimen for high risk renal tumours comprised cyclophosphamide, doxorubicin, vincristine and carboplatin, along with palliative radiation therapy but he developed disease progression. Consequently, the regimen was changed to COG protocol involving vincristine and irinotecan but no significant response was obtained. Hence, He started receiving a combination regimen of sorafenib and irinotecan which resulted in stable disease for nearly 8 weeks, but he experienced significant diarrhea. The man was advised to discontinue sorafenib and the treatment was changed to a combination of irinotecan, temsirolimus, and bevacizumab. Although, PET scan was negative, clinically progressive disease was developed under treatment and he died secondary to multisystem failure. Author comment: "It was decided to start the patient on a combination regimen consisting of Sorafenib plus Irinotecan. This combination resulted in stable disease for approximately 8 weeks. However, this combination caused significant diarrh[o]ea, and Sorafenib was stopped." Nelius T, et al. TFE3 translocation-associated renal cell carcinoma presenting as avascular necrosis of the femur in a 19-year-old patient: Case report and review of the literature. Case Reports in Medicine 2011: 14 Jul 2011. Available from: URL: http://doi.org/10.1155/2011/432917 - USA 803283898 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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