Reactions 1704, p207 - 2 Jun 2018 Sweet syndrome: case report A 79-year-old man developed Sweet syndrome during treatment with ipilimumab for metastatic melanoma [route not stated]. The man presented with several tender and purpuric plaques on the left hand, generalised malaise and fever. He had a history of stage IV BRAF wild-type metastatic melanoma with nodal, cerebral and pulmonary metastases and had been receiving therapy with ipilimumab 3 mg/kg every three weeks. He had received four doses before the onset of the cutaneous manifestations. A histopathological examination of a punch biopsy from his left hand showed an intensely neutrophilic dermal infiltrate with oedema, consistent with Sweet syndrome. A full blood examination showed leucocytosis and anaemia. He had a mildly elevated CRP level of 26 mg/dL. The man’s ipilimumab therapy was discontinued. He was treated with prednisolone and betamethasone dipropionate, and complete resolution of the cutaneous lesions was noted. He then started receiving nivolumab for the melanoma. Author comment: "In our case, the characteristic histopathological findings and temporally-related resolution with withdrawal of the drug support a diagnosis of ipilimumab-associated [Sweet syndrome], representing the fourth reported case in the scientific literature." Adler NR, et al. Sweet syndrome associated with ipilimumab in a patient with metastatic melanoma. Clinical and Experimental Dermatology 43: 497-499, No. 4, Jun 2018. Available from: URL: http://doi.org/10.1111/ced.13399 - Australia 803323462 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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