J. Membrane Biol. 163, 1–8 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review R.M. Henderson, R.D. Barber Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, United Kingdom Received: 31 July 1997/Revised: 29 September, 1997 Introduction highlighted by the case of angiotensin II, which causes depolarization and contraction in cultured mesangial cells, under apparently normal conditions, but may also Renal glomerular mesangial cells have an important role cause mesangial cell proliferation . The relationship in the maintenance of normal kidney function and in the between calcium signaling and cell proliferation is com- processes that lead to glomerular pathology. They are plex and has recently been reviewed . The multi- multifunctional, partly resembling vascular smooth functional role of the mesangial cell has made it difficult muscle cells, contracting in the presence of agents that for the electrophysiologist to study, but work in recent influence glomerular filtration, and partly taking on the role of macrophages. They secrete and are the target for years has meant that the role of ion channels even in the normal function of the mesangial cell is now becoming numerous inflammatory mediators and, since they also more clear.
The Journal of Membrane Biology – Springer Journals
Published: May 1, 1998
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