Ion Channel Roles in Cell Death Induction

Ion Channel Roles in Cell Death Induction J. Membrane Biol. 209, 1–2 (2006) DOI: 10.1007/s00232-005-0845-5 Thematic Issue Yasunobu Okada, Guest Editor Foreword Yasunobu Okada Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan Received: 25 January 2006/Online publication: 17 April 2006 Cell death occurs in both physiological and patho- termed apoptotic volume decrease (AVD), is accom- logical conditions in response to a number of signals plished by release of cell water driven mainly by efflux + ) and stresses. Alterations in membrane transport can of K and Cl , whereas the early-phase swelling of be not only the result of but also the cause of cell necrotic cells, termed necrotic volume increase (NVI), death. Some ion channels act as sensors or receptors is induced by water uptake driven mainly by influx of + ) for the cell death-related signals or stresses. Persistent Na and Cl . Therefore, it appears that both AVD cell shrinkage and swelling are major hallmarks of the and NVI involve activities of a number of ion chan- early phase of apoptotic and necrotic cell death, nels and/or transporters. On the other hand, it is well respectively, as schematically depicted in Fig. 1. The known that most animal cells after The Journal of Membrane Biology Springer Journals

Ion Channel Roles in Cell Death Induction

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Copyright © 2006 by Springer Science+Business Media, Inc.
Life Sciences; Human Physiology; Biochemistry, general
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