Loading next page...
/lp/springer_journal/involvement-of-nuclear-receptor-rev-erb-in-formation-of-neurites-and-haBNYsWCEg
- Publisher
- Springer Journals
- Copyright
- Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
- Subject
- Biomedicine; Neurosciences; Cell Biology; Neurobiology
- ISSN
- 0272-4340
- eISSN
- 1573-6830
- DOI
- 10.1007/s10571-018-0576-7
- pmid
- 29397477
- Publisher site
- See Article on Publisher Site
Abstract
Neural stem cells (NSCs) serve as the source of both neurons and support cells, and neurogenesis is reportedly linked to the circadian clock. This study aimed to clarify the functional role of the circadian rhythm-related nuclear receptor, REV-ERBβ, in neurogenesis of NSCs from adult brain. Accordingly, Rev-erbβ expression and the effect of Rev-erbβ gene-specific knockdown on neurogenesis in vitro was examined in adult rodent NSCs. Initial experiments confirmed REV-ERBβ expression in cultured adult NSCs, while subsequent gene expression and gene ontogeny analyses identified functional genes upregulated or downregulated by REV-ERBβ. In particular, expression levels of factors associated with proliferation, stemness, and neural differentiation were affected. Knockdown of Rev-erbβ showed involvement of REV-ERBβ in regulation of cellular proliferation and self-renewal of cultured adult NSCs. Moreover, Rev-erbβ-knockdown cells formed neurons with a slightly shrunken morphology, fewer new primary neurites, and reduced length and branch formation of neurites. Altogether, this suggests that REV-ERBβ is involved in neurite formation during neuronal differentiation of cultured adult NSCs. In summary, REV-ERBβ is a known circadian regulatory protein that appears to be involved in neurogenesis via regulation of networks for cell proliferation and neural differentiation/maturation in adult NSCs.
Journal
Cellular and Molecular Neurobiology – Springer Journals
Published: Feb 3, 2018
Recommended Articles
Loading...
References
-
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separationAimone, JB; Deng, W; Gage, FH
-
Hippocampal neurogenesis regulates forgetting during adulthood and infancyAkers, KG; Martinez-Canabal, A; Restivo, L; Yiu, AP; Cristofaro, A; Hsiang, HL; Wheeler, AL; Guskjolen, A; Niibori, Y; Shoji, H; Ohira, K; Richards, BA; Miyakawa, T; Josselyn, SA; Frankland, PW
-
Circadian kinetics of cell cycle progression in adult neurogenic niches of a diurnal vertebrateAkle, V; Stankiewicz, AJ; Kharchenko, V; Yu, L; Kharchenko, PV; Zhdanova, IV
-
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in ratsAltman, J; Das, GD
-
For the long run: maintaining germinal niches in the adult brainAlvarez-Buylla, A; Lim, DA
-
Plexin-B3 is a functional receptor for semaphorin 5AArtigiani, S; Conrotto, P; Fazzari, P; Gilestro, GF; Barberis, D; Giordano, S; Comoglio, PM; Tamagnone, L
-
Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathwaysBancroft, J; Auckland, P; Samora, CP; McAinsh, AD
-
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviourBanerjee, S; Wang, Y; Solt, LA; Griffett, K; Kazantzis, M; Amador, A; El-Gendy, BM; Huitron-Resendiz, S; Roberts, AJ; Shin, Y; Kamenecka, TM; Burris, TP
-
Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampusBorgs, L; Beukelaers, P; Vandenbosch, R; Nguyen, L; Moonen, G; Maquet, P; Albrecht, U; Belachew, S; Malgrange, B
-
The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exitBouchard-Cannon, P; Mendoza-Viveros, L; Yuen, A; Kaern, M; Cheng, HY
-
MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous systemBrandt-Bohne, U; Keene, DR; White, FA; Koch, M
-
Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic functionBugge, A; Feng, D; Everett, LJ; Briggs, ER; Mullican, SE; Wang, F; Jager, J; Lazar, MA
-
Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clockBurris, TP
-
Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-betaCho, H; Zhao, X; Hatori, M; Yu, RT; Barish, GD; Lam, MT; Chong, LW; DiTacchio, L; Atkins, AR; Glass, CK; Liddle, C; Auwerx, J; Downes, M; Panda, S; Evans, RM
-
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulationChung, S; Lee, EJ; Yun, S; Choe, HK; Park, SB; Son, HJ; Kim, KS; Dluzen, DE; Lee, I; Hwang, O; Son, GH; Kim, K
-
Subventricular zone astrocytes are neural stem cells in the adult mammalian brainDoetsch, F; Caille, I; Lim, DA; Garcia-Verdugo, JM; Alvarez-Buylla, A
-
Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brainDuncan, MJ; Prochot, JR; Cook, DH; Tyler Smith, J; Franklin, KM
-
Neurogenesis in the adult human hippocampusEriksson, PS; Perfilieva, E; Bjork-Eriksson, T; Alborn, AM; Nordborg, C; Peterson, DA; Gage, FH
-
Circadian clock genes and sleep homeostasisFranken, P; Dijk, DJ
-
Mammalian neural stem cellsGage, FH
-
An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cellsGoldberg, JL; Vargas, ME; Wang, JT; Mandemakers, W; Oster, SF; Sretavan, DW; Barres, BA
-
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neuronsGunnersen, JM; Kim, MH; Fuller, SJ; Silva, M; Britto, JM; Hammond, VE; Davies, PJ; Petrou, S; Faber, ES; Sah, P; Tan, SS
-
Cyclin E in normal and neoplastic cell cyclesHwang, HC; Clurman, BE
-
Oscillatory control of factors determining multipotency and fate in mouse neural progenitorsImayoshi, I; Isomura, A; Harima, Y; Kawaguchi, K; Kori, H; Miyachi, H; Fujiwara, T; Ishidate, F; Kageyama, R
-
Sleep and circadian rhythm disruption in neuropsychiatric illnessJagannath, A; Peirson, SN; Foster, RG
-
HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levelsJiang, Y; Hsieh, J
-
Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustnessJohnston, ST; Shtrahman, M; Parylak, S; Goncalves, JT; Gage, FH
-
Milestones of neuronal development in the adult hippocampusKempermann, G; Jessberger, S; Steiner, B; Kronenberg, G
-
BMAL1-dependent regulation of the mTOR signaling pathway delays agingKhapre, RV; Kondratova, AA; Patel, S; Dubrovsky, Y; Wrobel, M; Antoch, MP; Kondratov, RV
-
Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cellsKimiwada, T; Sakurai, M; Ohashi, H; Aoki, S; Tominaga, T; Wada, K
-
REV-ERB and ROR nuclear receptors as drug targetsKojetin, DJ; Burris, TP
-
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clockKondratov, RV; Kondratova, AA; Gorbacheva, VY; Vykhovanets, OV; Antoch, MP
-
Circadian clock proteins control adaptation to novel environment and memory formationKondratova, AA; Dubrovsky, YV; Antoch, MP; Kondratov, RV
-
NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycleLacomme, M; Liaubet, L; Pituello, F; Bel-Vialar, S
-
Circadian rhythm hypotheses of mixed features, antidepressant treatment resistance, and manic switching in bipolar disorderLee, HJ; Son, GH; Geum, D
-
Enumeration of neural stem and progenitor cells in the neural colony-forming cell assayLouis, SA; Rietze, RL; Deleyrolle, L; Wagey, RE; Thomas, TE; Eaves, AC; Reynolds, BA
-
Circadian clock genes are essential for normal adult neurogenesis, differentiation, and fate determinationMalik, A; Kondratov, RV; Jamasbi, RJ; Geusz, ME
-
Circadian genes, rhythms and the biology of mood disordersMcClung, CA
-
How might circadian rhythms control mood? Let me count the waysMcClung, CA
-
Adult neurogenesis in the mammalian brain: significant answers and significant questionsMing, GL; Song, H
-
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampusMira, H; Andreu, Z; Suh, H; Lie, DC; Jessberger, S; Consiglio, A; San Emeterio, J; Hortiguela, R; Marques-Torrejon, MA; Nakashima, K; Colak, D; Gotz, M; Farinas, I; Gage, FH
-
Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardationMolinari, F; Rio, M; Meskenaite, V; Encha-Razavi, F; Auge, J; Bacq, D; Briault, S; Vekemans, M; Munnich, A; Attie-Bitach, T; Sonderegger, P; Colleaux, L
-
Circadian clock proteins regulate neuronal redox homeostasis and neurodegenerationMusiek, ES; Lim, MM; Yang, G; Bauer, AQ; Qi, L; Lee, Y; Roh, JH; Ortiz-Gonzalez, X; Dearborn, JT; Culver, JP; Herzog, ED; Hogenesch, JB; Wozniak, DF; Dikranian, K; Giasson, BI; Weaver, DR; Holtzman, DM; Fitzgerald, GA
-
Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin bindingNigg, EA; Gallant, P; Krek, W
-
Cyclin A is required at two points in the human cell cyclePagano, M; Pepperkok, R; Verde, F; Ansorge, W; Draetta, G
-
Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenancePorlan, E; Morante-Redolat, JM; Marques-Torrejon, MA; Andreu-Agullo, C; Carneiro, C; Gomez-Ibarlucea, E; Soto, A; Vidal, A; Ferron, SR; Farinas, I
-
Survival of adult generated hippocampal neurons is altered in circadian arrhythmic miceRakai, BD; Chrusch, MJ; Spanswick, SC; Dyck, RH; Antle, MC
-
Differential properties of adult rat and mouse brain-derived neural stem/progenitor cellsRay, J; Gage, FH
-
The nuclear receptor REV-ERBalpha regulates Fabp7 and modulates adult hippocampal neurogenesisSchnell, A; Chappuis, S; Schmutz, I; Brai, E; Ripperger, JA; Schaad, O; Welzl, H; Descombes, P; Alberi, L; Albrecht, U
-
The role of CLOCK gene in psychiatric disorders: evidence from human and animal researchSchuch, JB; Genro, JP; Bastos, CR; Ghisleni, G; Tovo-Rodrigues, L
-
Expression and function of orphan nuclear receptor TLX in adult neural stem cellsShi, Y; Chichung Lie, D; Taupin, P; Nakashima, K; Ray, J; Yu, RT; Gage, FH; Evans, RM
-
Ten-eleven translocation 1 and 2 confer overlapping transcriptional programs for the proliferation of cultured adult neural stem cellsShimozaki, K
-
SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cellsShimozaki, K; Zhang, CL; Suh, H; Denli, AM; Evans, RM; Gage, FH
-
Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cellsShimozaki, K; Clemenson, GD; Gage, FH
-
Neurogenesis in the adult is involved in the formation of trace memoriesShors, TJ; Miesegaes, G; Beylin, A; Zhao, M; Rydel, T; Gould, E
-
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonistsSolt, LA; Wang, Y; Banerjee, S; Hughes, T; Kojetin, DJ; Lundasen, T; Shin, Y; Liu, J; Cameron, MD; Noel, R; Yoo, SH; Takahashi, JS; Butler, AA; Kamenecka, TM; Burris, TP
-
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decisionSong, J; Zhong, C; Bonaguidi, MA; Sun, GJ; Hsu, D; Gu, Y; Meletis, K; Huang, ZJ; Ge, S; Enikolopov, G; Deisseroth, K; Luscher, B; Christian, KM; Ming, GL; Song, H
-
Time-of-day-dependent enhancement of adult neurogenesis in the hippocampusTamai, S; Sanada, K; Fukada, Y
-
Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domainsYan, J; Kuroyanagi, H; Tomemori, T; Okazaki, N; Asato, K; Matsuda, Y; Suzuki, Y; Ohshima, Y; Mitani, S; Masuho, Y; Shirasawa, T; Muramatsu, M
-
Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific geneYu, ZL; Jiang, JM; Wu, DH; Xie, HJ; Jiang, JJ; Zhou, L; Peng, L; Bao, GS
-
A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cellsZenker, J; Stettner, M; Ruskamo, S; Domenech-Estevez, E; Baloui, H; Medard, JJ; Verheijen, MH; Brouwers, JF; Kursula, P; Kieseier, BC; Chrast, R
-
A role for adult TLX-positive neural stem cells in learning and behaviourZhang, CL; Zou, Y; He, W; Gage, FH; Evans, RM
-
Tet1 regulates adult hippocampal neurogenesis and cognitionZhang, RR; Cui, QY; Murai, K; Lim, YC; Smith, ZD; Jin, S; Ye, P; Rosa, L; Lee, YK; Wu, HP; Liu, W; Xu, ZM; Yang, L; Ding, YQ; Tang, F; Meissner, A; Ding, C; Shi, Y; Xu, GL
-
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampusZhao, C; Teng, EM; Summers, RG; Ming, GL; Gage, FH
-
Mechanisms and functional implications of adult neurogenesisZhao, C; Deng, W; Gage, FH
-
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axonsZhou, X; Babu, JR; Silva, S; Shu, Q; Graef, IA; Oliver, T; Tomoda, T; Tani, T; Wooten, MW; Wang, F
@Phil_Robichaud
@deepthiw
@JoseServera