Involvement of Gap Junctions in Stimulation of in vitroMaturation of the Common Frog Oocytes by Low Progesterone Concentrations

Involvement of Gap Junctions in Stimulation of in vitroMaturation of the Common Frog Oocytes by... The inhibitor of gap junctions 18α-glycerretinic acid inhibits the maturation of follicle-enclosed common frog oocytes stimulated by low progesterone concentrations. The inhibitory effect of 18α-glycyrrhetinic acid does not depend on concentrations within the limits of 5–40 μM. The progesterone concentrations, at which oocyte maturation can be inhibited, differed markedly in different females. The inhibitory effects of actinomycin D (5 μg/ml) and 18α-glycyrrhetinic acid (5 μg/ml) were expressed when the same progesterone concentrations were used. When injected in an intact oocyte, Lucifer yellow was transferred into the follicle cells, thus suggesting the presence of gap junction between these latter and the oocyte. The data obtained suggest that the previously described transcription-dependent factor formed in the follicle cells under the influence of low progesterone concentrations and stimulating oocyte maturation is transferred in the oocyte via gap junctions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Involvement of Gap Junctions in Stimulation of in vitroMaturation of the Common Frog Oocytes by Low Progesterone Concentrations

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1023/B:RUDO.0000043821.87268.ca
Publisher site
See Article on Publisher Site

Abstract

The inhibitor of gap junctions 18α-glycerretinic acid inhibits the maturation of follicle-enclosed common frog oocytes stimulated by low progesterone concentrations. The inhibitory effect of 18α-glycyrrhetinic acid does not depend on concentrations within the limits of 5–40 μM. The progesterone concentrations, at which oocyte maturation can be inhibited, differed markedly in different females. The inhibitory effects of actinomycin D (5 μg/ml) and 18α-glycyrrhetinic acid (5 μg/ml) were expressed when the same progesterone concentrations were used. When injected in an intact oocyte, Lucifer yellow was transferred into the follicle cells, thus suggesting the presence of gap junction between these latter and the oocyte. The data obtained suggest that the previously described transcription-dependent factor formed in the follicle cells under the influence of low progesterone concentrations and stimulating oocyte maturation is transferred in the oocyte via gap junctions.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Dec 30, 2004

References

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