Loss of full-thickness skin over a large body area repre- showed thin pink neodermal tissue. The final result was sents one of the major challenges in reconstructive sur- natural and the tissue was elastic and traction resistant. gery. In burned patients this problem is particularly sig- Sixteen days is the period required to obtain a vascu- nificant because the prognosis has improved following larized neodermis. During this period, in which the porous the introduction of early escarectomy, but this procedure matrix of fibers of cross-linked bovine tendon collagen can expose the patient to the risk of insufficient autolo- and glycosaminoglycan are biodegraded and the ingrow- gous tissue for immediate cover. ing fibroblasts create a neodermis, the Integra has to stay Large third degree burn surfaces introduce new techni- fixed to the wound bed. cal challenges which we still look forward to solving. If this process is successful, at the end of the treatment Preparation of the recipient bed for the autologous skin there will be no thick granulating tissue and no sign of is one of the topical subjects. Homologous skin grafts chronic infection. Prevention of granulating tissue growth as eterologous grafts, fresh or preserved, have been tried is
European Journal of Plastic Surgery – Springer Journals
Published: Apr 15, 1999
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