Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis

Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach... Metabolomics (2017) 13:111 DOI 10.1007/s11306-017-1251-6 ORIGINAL ARTICLE Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis 1 1 2 3 Ravindra Taware  · Khushman Taunk  · Jorge A. M. Pereira  · Rahul Dhakne  · 4 4 2,5 3,6 Narayanan Kannan  · Dharmesh Soneji  · José S. Câmara  · H. A. Nagarajaram  · Srikanth Rapole   Received: 25 May 2017 / Accepted: 14 August 2017 © Springer Science+Business Media, LLC 2017 Abstract Methods Volatomic analysis of urine samples collected Introduction Head and neck cancer (HNC), like many from HNC patients (n = 29) and healthy controls (n = 31) other forms of cancer, is usually detected in advanced stages, was performed using headspace solid phase microextraction causing poor survival outcomes. Lack of specific and sensi- coupled to gas chromatography mass spectrometry (GC– tive screening markers for early detection of HNC has wors- MS). Both univariate and multivariate statistical approaches ened the scenario for the patients as well as the clinicians. were used to investigate HNC specific volatomic alterations. Therefore, identification of efficient, noninvasive and afford- Results Statistical analysis revealed a total of 28 metabo- able screening marker/methodology with high specificity lites with highest contribution towards discrimination of and sensitivity is imminent need of situation. HNC patients from healthy controls (VIP >1, Metabolomics Springer Journals

Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis

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Springer US
Copyright © 2017 by Springer Science+Business Media, LLC
Life Sciences; Biochemistry, general; Molecular Medicine; Cell Biology; Developmental Biology; Biomedicine, general
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