Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis

Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach... Metabolomics (2017) 13:111 DOI 10.1007/s11306-017-1251-6 ORIGINAL ARTICLE Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis 1 1 2 3 Ravindra Taware  · Khushman Taunk  · Jorge A. M. Pereira  · Rahul Dhakne  · 4 4 2,5 3,6 Narayanan Kannan  · Dharmesh Soneji  · José S. Câmara  · H. A. Nagarajaram  · Srikanth Rapole   Received: 25 May 2017 / Accepted: 14 August 2017 © Springer Science+Business Media, LLC 2017 Abstract Methods Volatomic analysis of urine samples collected Introduction Head and neck cancer (HNC), like many from HNC patients (n = 29) and healthy controls (n = 31) other forms of cancer, is usually detected in advanced stages, was performed using headspace solid phase microextraction causing poor survival outcomes. Lack of specific and sensi- coupled to gas chromatography mass spectrometry (GC– tive screening markers for early detection of HNC has wors- MS). Both univariate and multivariate statistical approaches ened the scenario for the patients as well as the clinicians. were used to investigate HNC specific volatomic alterations. Therefore, identification of efficient, noninvasive and afford- Results Statistical analysis revealed a total of 28 metabo- able screening marker/methodology with high specificity lites with highest contribution towards discrimination of and sensitivity is imminent need of situation. HNC patients from healthy controls (VIP >1, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Metabolomics Springer Journals

Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis

Loading next page...
 
/lp/springer_journal/investigation-of-urinary-volatomic-alterations-in-head-and-neck-cancer-1qncclnU4s
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Life Sciences; Biochemistry, general; Molecular Medicine; Cell Biology; Developmental Biology; Biomedicine, general
ISSN
1573-3882
eISSN
1573-3890
D.O.I.
10.1007/s11306-017-1251-6
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial