Pharm Med (2018) 32:209–217 https://doi.org/10.1007/s40290-018-0237-7 ORIGINAL RESEARCH ARTICLE Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic Agents Using the Japanese Adverse Drug Event Report Database 1 1 1 • • Yomei Matsuoka Masayuki Kaneko Mamoru Narukawa Published online: 2 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract consideration when making their observations, with more Background With the aging of the population, it is careful observation in elderly patients. expected that the number of elderly people with inﬂam- matory rheumatic diseases will continue to increase. Objective The purpose of this study was to provide useful Key Points information for risk minimization of antirheumatic agents using the Japanese Adverse Drug Event Report database The incidence of infections increased with age in through investigation of the inﬂuence of aging on adverse patients treated with antirheumatic agents. events (AEs) in patients treated with tumor necrosis factor- The Japanese Adverse Drug Event Report (JADER) a inhibitors (TNF-Is) or methotrexate (MTX). database is considered to reﬂect actual clinical Methods Infections and malignant tumors were selected as practice in the postmarketing stage. typical serious AEs for antirheumatic agents, which are indicated in the treatment guidelines for rheumatoid
Pharmaceutical Medicine – Springer Journals
Published: Jun 2, 2018
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