Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic Agents Using the Japanese Adverse Drug Event Report Database

Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic... Pharm Med (2018) 32:209–217 https://doi.org/10.1007/s40290-018-0237-7 ORIGINAL RESEARCH ARTICLE Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic Agents Using the Japanese Adverse Drug Event Report Database 1 1 1 • • Yomei Matsuoka Masayuki Kaneko Mamoru Narukawa Published online: 2 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract consideration when making their observations, with more Background With the aging of the population, it is careful observation in elderly patients. expected that the number of elderly people with inflam- matory rheumatic diseases will continue to increase. Objective The purpose of this study was to provide useful Key Points information for risk minimization of antirheumatic agents using the Japanese Adverse Drug Event Report database The incidence of infections increased with age in through investigation of the influence of aging on adverse patients treated with antirheumatic agents. events (AEs) in patients treated with tumor necrosis factor- The Japanese Adverse Drug Event Report (JADER) a inhibitors (TNF-Is) or methotrexate (MTX). database is considered to reflect actual clinical Methods Infections and malignant tumors were selected as practice in the postmarketing stage. typical serious AEs for antirheumatic agents, which are indicated in the treatment guidelines for rheumatoid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Medicine Springer Journals

Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic Agents Using the Japanese Adverse Drug Event Report Database

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmaceutical Sciences/Technology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1178-2595
eISSN
1179-1993
D.O.I.
10.1007/s40290-018-0237-7
Publisher site
See Article on Publisher Site

Abstract

Pharm Med (2018) 32:209–217 https://doi.org/10.1007/s40290-018-0237-7 ORIGINAL RESEARCH ARTICLE Investigation into the Impact of Aging on Serious Adverse Events Associated with Antirheumatic Agents Using the Japanese Adverse Drug Event Report Database 1 1 1 • • Yomei Matsuoka Masayuki Kaneko Mamoru Narukawa Published online: 2 June 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract consideration when making their observations, with more Background With the aging of the population, it is careful observation in elderly patients. expected that the number of elderly people with inflam- matory rheumatic diseases will continue to increase. Objective The purpose of this study was to provide useful Key Points information for risk minimization of antirheumatic agents using the Japanese Adverse Drug Event Report database The incidence of infections increased with age in through investigation of the influence of aging on adverse patients treated with antirheumatic agents. events (AEs) in patients treated with tumor necrosis factor- The Japanese Adverse Drug Event Report (JADER) a inhibitors (TNF-Is) or methotrexate (MTX). database is considered to reflect actual clinical Methods Infections and malignant tumors were selected as practice in the postmarketing stage. typical serious AEs for antirheumatic agents, which are indicated in the treatment guidelines for rheumatoid

Journal

Pharmaceutical MedicineSpringer Journals

Published: Jun 2, 2018

References

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