Mamm Genome (2015) 26:271 DOI 10.1007/s00335-015-9594-7 Introduction to Mammalian Genome special issue: Informatics and Integrative Genomics—Part 1 Ann-Marie Mallon Published online: 7 August 2015 Springer Science+Business Media New York 2015 Last year, we celebrated 25 years of the Mouse Genome MGI data is the mouse reference genome and gene set. The Informatics (MGI) resource from the Jackson Laboratory. article by Yunzia Zhu et al. focuses on the process of The development of MGI and other global bioinformatics building this uniﬁed mouse gene catalog. Following on resources and analytical methodologies has accelerated from this, Mary Dolan et al. describe how the mouse gene over this 25-year period in a vast array of scientiﬁc disci- catalog is associated with orthologous human genes to plines and across many research groups. Informatics and enable comparative genomics. integrative genomics is a huge ﬁeld, driving forward new The review of the MGI Gene Expression Database areas of insight in many aspects of mouse genetics and (GXD) by Constance Smith et.al describes an integral part functional genomics. In this special issue, we are focusing of the MGI resource which enables users to access a vast on reviewing the breadth of work in the larger global array of gene expression data in the context of other bioinformatics infrastructure that underpins this area. genetic-, functional-, phenotypic-, and disease-orientated The special issue is broken into two parts, with Part 1 data. Data accessibility is a key component of bioinfor- reﬂecting on the 25 years of MGI. Part 1 begins with a matics, and Howie Motenko et al. describe a new tool historical perspective of MGI by Janan Eppig and col- MouseMine, which is built on the InterMine framework to leagues reviewing how MGI has changed over the last provide a new data warehouse for accessing mouse data quarter of a century and what plans are in place for the from MGI. future. The review by Susan Bello et al. describes the The special issue will continue in Part 2, to cover a vast Allele, Phenotype, and Disease data within MGI and plans array of other bioinformatics aspects from global mouse in place to improve access and analysis. The use of mouse infrastructures, to underpinning resources for the reference phenotype data to drive translational research into human populations, complex trait analysis, mutagenesis, and disease has expanded rapidly, and this review describes embryonic imaging to a ﬁnal section on integrative geno- methods implemented in MGI to enable researchers to mics which will focus on cross-species applications. identify novel human disease genes. Underlying all of the & Ann-Marie Mallon email@example.com MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0RD, UK
Mammalian Genome – Springer Journals
Published: Aug 7, 2015
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