Mamm Genome (2017) 28:235–236 DOI 10.1007/s00335-017-9708-5 Introduction to Mammalian Genome Special Issue: Genome Editing 1 2,3,4,5,6 7 8 Lydia Teboul · Yann Hérault · Cynthia Smith · Bruce Whitelaw Published online: 15 July 2017 © Springer Science+Business Media, LLC 2017 Not quite 5 years on, the repurposing of the CRISPR sys- nucleases and transcription activator-like effector nucleases tem for genome engineering has fundamentally changed (TALENs). These initial advances provided new possibili- how we think about biomedical research and modelling. It ties in terms of the type of genome modifications and the has extended the range of genome manipulations that are experimental models that realistically could be accessed. possible, shrunk timelines as well as the cost of in vivo However, both the cost and intricacies of optimisation and genome engineering, and has created many models for implementation of these new tools restricted their broad in vitro experimentation. We present a special issue of adoption in research. Mammalian Genome that takes stock of these advances and The introduction to the field of simple CRISPR-derived places them in the broad context of genomics. molecules for genome editing changed this. This issue As with all revolutions, although it seemed to take the brings together reviews that summarise
Mammalian Genome – Springer Journals
Published: Jul 15, 2017
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