Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Intravoxel incoherent motion magnetic resonance imaging for differentiating metastatic and non-metastatic lymph nodes in pancreatic ductal adenocarcinoma

Intravoxel incoherent motion magnetic resonance imaging for differentiating metastatic and... Objectives To evaluate the diagnostic potential of intravoxel incoherent motion (IVIM) DWI for differentiating metastatic and non-metastatic lymph node stations (LNS) in pancreatic ductal adenocarcinoma (PDAC). Methods 59 LNS histologically diagnosed following surgical resection from 15 patients were included. IVIM DWI with 12 b values was added to the standard MRI protocol. Evaluation of parameters was performed pre-operatively and included the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f). Diagnostic performance of ADC, D, D* and f for differentiating between metastatic and non-metastatic LNS was evaluated using ROC analysis. Results Metastatic LNS had significantly lower D, D*, f and ADC values than the non-metastatic LNS (p< 0.01). The best diagnostic performance was found in D, with an area under the ROC curve of 0.979, while the area under the ROC curve values of D*, f and ADC were 0.867, 0.855 and 0.940, respectively. The optimal cut-off values for distinguishing metastatic and non- −3 2 −3 2 −3 2 metastatic lymph nodes were D = 1.180 × 10 mm /s; D* = 14.750 × 10 mm /s, f = 20.65 %, and ADC = 1.390 × 10 mm /s. Conclusion IVIM DWI is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Radiology Springer Journals

Intravoxel incoherent motion magnetic resonance imaging for differentiating metastatic and non-metastatic lymph nodes in pancreatic ductal adenocarcinoma

Download PDF
9 pages

Loading next page...
 
/lp/springer_journal/intravoxel-incoherent-motion-magnetic-resonance-imaging-for-5DKl1HouAa
Publisher
Springer Journals
Copyright
Copyright © 2018 by European Society of Radiology
Subject
Medicine & Public Health; Imaging / Radiology; Diagnostic Radiology; Interventional Radiology; Neuroradiology; Ultrasound; Internal Medicine
ISSN
0938-7994
eISSN
1432-1084
DOI
10.1007/s00330-017-5259-0
pmid
29404768
Publisher site
See Article on Publisher Site

Abstract

Objectives To evaluate the diagnostic potential of intravoxel incoherent motion (IVIM) DWI for differentiating metastatic and non-metastatic lymph node stations (LNS) in pancreatic ductal adenocarcinoma (PDAC). Methods 59 LNS histologically diagnosed following surgical resection from 15 patients were included. IVIM DWI with 12 b values was added to the standard MRI protocol. Evaluation of parameters was performed pre-operatively and included the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f). Diagnostic performance of ADC, D, D* and f for differentiating between metastatic and non-metastatic LNS was evaluated using ROC analysis. Results Metastatic LNS had significantly lower D, D*, f and ADC values than the non-metastatic LNS (p< 0.01). The best diagnostic performance was found in D, with an area under the ROC curve of 0.979, while the area under the ROC curve values of D*, f and ADC were 0.867, 0.855 and 0.940, respectively. The optimal cut-off values for distinguishing metastatic and non- −3 2 −3 2 −3 2 metastatic lymph nodes were D = 1.180 × 10 mm /s; D* = 14.750 × 10 mm /s, f = 20.65 %, and ADC = 1.390 × 10 mm /s. Conclusion IVIM DWI is

Journal

European Radiology – Springer Journals

Published: Feb 5, 2018

References

  • Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection
    Becker, AE; Hernandez, YG; Frucht, H; Lucas, AL
  • Pancreatic Cancer Diagnostics and Treatment--Current State
    Krska, Z; Svab, J; Hoskovec, D; Ulrych, J
  • Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients
    Lim, JE; Chien, MW; Earle, CC
  • Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database
    Schwarz, RE; Smith, DD
  • Comparison of preoperative imaging and pathological findings for pancreatic head adenocarcinoma: A retrospective analysis by the Association Francaise de Chirurgie
    Gilabert, M; Boher, JM; Raoul, JL
  • A prospective diagnostic accuracy study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography, multidetector row computed tomography, and magnetic resonance imaging in primary diagnosis and staging of pancreatic cancer
    Kauhanen, SP; Komar, G; Seppanen, MP
  • Diagnostic accuracy of CT in assessing extra-regional lymphadenopathy in pancreatic and peri-ampullary cancer: a systematic review and meta-analysis
    Tseng, DS; Santvoort, HC; Fegrachi, S
  • Utility of contrast-enhanced FDG-PET/CT in the clinical management of pancreatic cancer: impact on diagnosis, staging, evaluation of treatment response, and detection of recurrence
    Asagi, A; Ohta, K; Nasu, J
  • Preoperative imaging for resectable periampullary cancer: clinicopathologic implications of reported radiographic findings
    Fong, ZV; Tan, WP; Lavu, H
  • Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer
    Imai, H; Doi, R; Kanazawa, H
  • Preoperative staging and tumor resectability assessment of pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography
    Soriano, A; Castells, A; Ayuso, C
  • MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders
    Le, BD; Breton, E; Lallemand, D; Grenier, P; Cabanis, E; Lavaljeantet, M
  • Discrimination between Metastatic and Nonmetastatic Mesorectal Lymph Nodes in Rectal Cancer Using Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging
    Yu, XP; Wen, L; Hou, J
  • Role of quantitative intravoxel incoherent motion parameters in the preoperative diagnosis of nodal metastasis in patients with rectal carcinoma
    Qiu, L; Liu, XL; Liu, SR
  • A preliminary exploration of the intravoxel incoherent motion applied in the preoperative evaluation of mediastinal lymph node metastasis of lung cancer
    Ye, X; Chen, S; Tian, Y
  • Lymph node metastasis in head and neck squamous carcinoma: Efficacy of intravoxel incoherent motion magnetic resonance imaging for the differential diagnosis
    Liang, L; Luo, X; Lian, Z
  • WHO classification of tumours of the digestive system
    Bosman, FT
  • Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma
    Westgaard, A; Tafjord, S; Farstad, IN
  • Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater
    Chang, DK; Jamieson, NB; Johns, AL
  • Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging: a modest proposal with tremendous potential
    Dixon, WT
  • An Algorithm for Least-Squares Estimation of Nonlinear Parameters
    Marquardt, DW
  • Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals
    Capurso, G; Signoretti, M; Valente, R
  • Differentiation of pancreas carcinoma from healthy pancreatic tissue using multiple b-values: comparison of apparent diffusion coefficient and intravoxel incoherent motion derived parameters
    Lemke, A; Laun, FB; Klauss, M
  • Diffusion-weighted magnetic resonance imaging of pancreatic adenocarcinomas: Association with histopathology and tumor grade
    Yi, WM; Chen, ZE; Paul Nikolaidis, MD
  • Pancreatic diffusion-weighted imaging (DWI): comparison between mass-forming focal pancreatitis (FP), pancreatic cancer (PC), and normal pancreas
    Fattahi, R; Balci, NC; Perman, WH
  • IVIM DW-MRI of autoimmune pancreatitis: therapy monitoring and differentiation from pancreatic cancer
    Klauss, M; Maier-Hein, K; Tjaden, C; Hackert, T; Grenacher, L; Stieltjes, B
  • Comparing primary tumors and metastatic nodes in head and neck cancer using intravoxel incoherent motion imaging: a preliminary experience
    Lu, Y; Jansen, JF; Stambuk, HE
  • Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver
    Kwee, TC; Takahara, T; Niwa, T
  • The effect of low b-values on the intravoxel incoherent motion derived pseudodiffusion parameter in liver
    Cohen, AD; Schieke, MC; Hohenwalter, MD; Schmainda, KM
  • An intravoxel incoherent motion diffusion-weighted imaging study of prostate cancer
    Shinmoto, H; Tamura, C; Soga, S
  • Diffusion-weighted MR imaging of the pancreas: optimizing b-value for visualization of pancreatic adenocarcinoma
    Fukukura, Y; Shindo, T; Hakamada, H
  • Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study
    Luciani, A; Vignaud, A; Cavet, M
  • Differentiation of pancreas carcinoma from healthy pancreatic tissue using multiple b-values: comparison of apparent diffusion coefficient and intravoxel incoherent motion derived parameters
    Lemke, A; Laun, FB; Klauss, M
  • Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging
    Yamada, I; Aung, W; Himeno, Y; Nakagawa, T; Shibuya, H
  • Toward an optimal distribution of b values for intravoxel incoherent motion imaging
    Lemke, A; Stieltjes, B; Schad, LR; Laun, FB
  • Intravoxel incoherent motion diffusion-weighted MR imaging of the liver: effect of triggering methods on regional variability and measurement repeatability of quantitative parameters
    Lee, Y; Lee, SS; Kim, N
  • Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs
    Barbieri, S; Donati, OF; Froehlich, JM; Thoeny, HC