Acta Neurochir (2017) 159:1721–1726 DOI 10.1007/s00701-017-3255-4 ORIGINAL ARTICLE - FUNCTIONAL Intraoperative clinical testing overestimates the therapeutic window of the permanent DBS electrode in the subthalamic nucleus 1,2 2,3 2 2,3 4 Josefine Blume & J. Schlaier & E. Rothenfußer & J. Anthofer & F. Zeman & 3 1,2,3,4 2,3 A. Brawanski & U. Bogdahn & M. Lange Received: 1 May 2017 /Accepted: 19 June 2017 /Published online: 12 July 2017 Springer-Verlag GmbH Austria 2017 Abstract whereas sufficient therapeutic effects were achieved at signif- Background Intraoperative test stimulation is established to icantly higher thresholds (P <0.001). optimize target localization in STN DBS, but requires a Conclusions Intraoperative testing may lead to an overestima- time-consuming awake surgery in off-medication state. The tion of the therapeutic window. The two different electrodes aim of this study was to compare the thresholds of lead to distinct spreading of the electric field in the STN and stimulation-induced effects of test stimulation and the perma- surrounding tissues that causes different volume of tissue ac- nent electrode. tivated (VTA). Clinicians involved in DBS surgery and pro- Methods Fifty-nine PD patients receiving bilateral STN DBS gramming should be aware of the differences in both stimula- were clinically examined
Acta Neurochirurgica – Springer Journals
Published: Jul 12, 2017
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