Intracerebroventricular Injection of NMDA Receptor Antagonist Affects l-Arginine Induced Food Intake in Neonatal Layer Chicks

Intracerebroventricular Injection of NMDA Receptor Antagonist Affects l-Arginine Induced Food... Nowadays inquiry of possible interplay between different neurotransmitters in brain function is one of the major fields of interest for researchers. In the current study, we aimed to survey interaction between glutamatergic and nitrergic systems on food intake in layers. In this regards, total of 308 one-day-old female layer-type chicks divided to 28 groups of 11 individuals in 7 defined experiments. All chickens were kept 3 h food deprived and used for intracerebroventricular (ICV) injection in the 5 day olds. In experiments 1–5, treatment groups received ICV injection of 10 µl control solution, l -arginine (precursor of NO synthesis; 800 nmol). In addition, birds administrated by different antagonists of glutamatergic receptors including MK-801 (NMDA receptor antagonist; 15 nmol), CNQX (AMPA/kainate receptor antagonist; 390 nmol), AIDA (mGLUR1 glutamate receptor antagonist; 2 nmol), LY341495 (mGLUR2 glutamate receptor antagonist; 150 nmol), UBP1112 (mGLUR3 glu- tamate receptor antagonist; 2 nmol) besides combination of mentioned antagonists of glutamatergic receptors + l -arginine (800 nmol). In the experiment 6, groups injected by control solution, glutamate (300 nmol), l -NAME (100 nmol) besides combination of both drugs. In the experiment 7, birds were ICV injected by control solution, glutamate (75 nmol), l -arginine (200 nmol) and combination of glutamate + l -arginine. Then cumulative food intake measured as following a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Peptide Research and Therapeutics Springer Journals

Intracerebroventricular Injection of NMDA Receptor Antagonist Affects l-Arginine Induced Food Intake in Neonatal Layer Chicks

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Animal Anatomy / Morphology / Histology; Polymer Sciences; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Molecular Medicine
ISSN
1573-3149
eISSN
1573-3904
D.O.I.
10.1007/s10989-018-9720-y
Publisher site
See Article on Publisher Site

Abstract

Nowadays inquiry of possible interplay between different neurotransmitters in brain function is one of the major fields of interest for researchers. In the current study, we aimed to survey interaction between glutamatergic and nitrergic systems on food intake in layers. In this regards, total of 308 one-day-old female layer-type chicks divided to 28 groups of 11 individuals in 7 defined experiments. All chickens were kept 3 h food deprived and used for intracerebroventricular (ICV) injection in the 5 day olds. In experiments 1–5, treatment groups received ICV injection of 10 µl control solution, l -arginine (precursor of NO synthesis; 800 nmol). In addition, birds administrated by different antagonists of glutamatergic receptors including MK-801 (NMDA receptor antagonist; 15 nmol), CNQX (AMPA/kainate receptor antagonist; 390 nmol), AIDA (mGLUR1 glutamate receptor antagonist; 2 nmol), LY341495 (mGLUR2 glutamate receptor antagonist; 150 nmol), UBP1112 (mGLUR3 glu- tamate receptor antagonist; 2 nmol) besides combination of mentioned antagonists of glutamatergic receptors + l -arginine (800 nmol). In the experiment 6, groups injected by control solution, glutamate (300 nmol), l -NAME (100 nmol) besides combination of both drugs. In the experiment 7, birds were ICV injected by control solution, glutamate (75 nmol), l -arginine (200 nmol) and combination of glutamate + l -arginine. Then cumulative food intake measured as following a

Journal

International Journal of Peptide Research and TherapeuticsSpringer Journals

Published: Jun 2, 2018

References

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