Intracellular localization of human respiratory syncytial virus L protein

Intracellular localization of human respiratory syncytial virus L protein Replication and transcription of the human respiratory syncytial virus (hRSV) genome is carried out by the ribonucleocapsid complex (RNA together with N, P, M2-1 and L proteins), with the L protein being responsible for all enzymatic activities. In the present study, we obtained anti-L polyclonal sera in mice. These antibodies were functional in immunofluorescence and Western blotting assays in hRSV-infected HEp-2 cells. In the immunofluorescence assays, we detected inclusion bodies in the anti-L staining, similar to the ones seen by anti-N or anti-P staining. The results presented here provide the first evidence of the intracellular localization of the hRSV L protein. Archives of Virology Springer Journals

Intracellular localization of human respiratory syncytial virus L protein

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Copyright © 2007 by Springer-Verlag
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
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