Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation

Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After... Adv Ther (2017) 34:1928–1935 DOI 10.1007/s12325-017-0583-y ORIGINAL RESEARCH Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation . . . Miltiadis Fiorentzis Arne Viestenz Anja Viestenz Berthold Seitz Received: May 28, 2017 / Published online: June 30, 2017 Springer Healthcare Ltd. 2017 after a period of 6 weeks and 3 months. Results ABSTRACT were compared using the Wilcoxon signed-rank test. Introduction: The aim of this observational Results: BCVA of the patients in the study study is to evaluate the effectiveness of an group increased from logMAR 1.5 ± 0.77 at adjuvant intracameral corticosteroid injection baseline to 0.99 ± 0.44 (p = 0.009) at 6 weeks (ICI) in cases of severe endothelial immune and to 0.78 ± 0.45 (p = 0.017) at 3 months fol- reaction (SEIR) (anterior chamber cells and flare, lowing the ICI. The CCT decreased from retrocorneal precipitates, Descemet’s folds, and 835 ± 211 lm at baseline to 609 ± 63 lm corneal edema) after penetrating keratoplasty (p = 0.005) after 3 months. ECC showed a sig- and posterior lamellar keratoplasty. nificant reduction 12 weeks after treatment in Methods: In this retrospective study, 24 sub- both http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advances in Therapy Springer Journals

Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation

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Publisher
Springer Healthcare
Copyright
Copyright © 2017 by Springer Healthcare Ltd.
Subject
Medicine & Public Health; Internal Medicine; Oncology; Cardiology; Rheumatology; Endocrinology; Pharmacology/Toxicology
ISSN
0741-238X
eISSN
1865-8652
D.O.I.
10.1007/s12325-017-0583-y
Publisher site
See Article on Publisher Site

Abstract

Adv Ther (2017) 34:1928–1935 DOI 10.1007/s12325-017-0583-y ORIGINAL RESEARCH Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation . . . Miltiadis Fiorentzis Arne Viestenz Anja Viestenz Berthold Seitz Received: May 28, 2017 / Published online: June 30, 2017 Springer Healthcare Ltd. 2017 after a period of 6 weeks and 3 months. Results ABSTRACT were compared using the Wilcoxon signed-rank test. Introduction: The aim of this observational Results: BCVA of the patients in the study study is to evaluate the effectiveness of an group increased from logMAR 1.5 ± 0.77 at adjuvant intracameral corticosteroid injection baseline to 0.99 ± 0.44 (p = 0.009) at 6 weeks (ICI) in cases of severe endothelial immune and to 0.78 ± 0.45 (p = 0.017) at 3 months fol- reaction (SEIR) (anterior chamber cells and flare, lowing the ICI. The CCT decreased from retrocorneal precipitates, Descemet’s folds, and 835 ± 211 lm at baseline to 609 ± 63 lm corneal edema) after penetrating keratoplasty (p = 0.005) after 3 months. ECC showed a sig- and posterior lamellar keratoplasty. nificant reduction 12 weeks after treatment in Methods: In this retrospective study, 24 sub- both

Journal

Advances in TherapySpringer Journals

Published: Jun 30, 2017

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