Clin Drug Investig (2017) 37:819–831 DOI 10.1007/s40261-017-0553-9 SYSTEMATIC REVIEW Interventions for Refractory Trigeminal Neuralgia: A Bayesian Mixed Treatment Comparison Network Meta-Analysis of Randomized Controlled Clinical Trials 1 2 Kannan Sridharan Gowri Sivaramakrishnan Published online: 17 July 2017 Springer International Publishing AG 2017 Abstract placebo based on pooled estimates in a Forest plot. In the Introduction Patients with trigeminal neuralgia (TN) are latter group, conventional radiofrequency (both standalone often refractory to recommended ﬁrst-line agents. Due to and in combination with pulsed radiofrequency) was found the absence of a systematic review, we undertook a net- to be better than pulsed radiofrequency alone. Rankogram work meta-analysis to assess various interventions that can plots revealed sumatriptan and combined continuous and be used to manage refractory TN. pulsed radiofrequency thermocoagualtion have the highest Methods Electronic databases were searched using appro- probability of being the best treatments in the respective priate strategies to identify randomized controlled clinical group of interventions. No inconsistency was observed trials in patients with refractory TN, evaluating the proportion between direct and indirect comparisons. of patients with a minimum of 50% reduction in pain or a Conclusion We found that drug-related interventions that minimum of 2 cm reduction in score in
Clinical Drug Investigation – Springer Journals
Published: Jul 17, 2017
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