A relationship between chronic hepatitis C virus (HCV) infection and interleukin-10 (IL-10) gene polymorphisms has been reported with controversial results in different studies. In an effort to solve this controversy, we quantitatively summarized ten studies on this relationship by means of meta-analysis. Our analysis included ten case–control studies with 992 cases of chronic HCV infection and 1,123 controls. Analyses were performed with STATA version 9.0. The results showed that the IL-10 −1082GG genotype significantly increased the risk for persistent HCV infection (AA vs. GG: OR = 0.680, 95% CI = 0.489−0.947, P = 0.022; AG vs. GG: OR = 0.608, 95% CI = 0.439−0.840, P = 0.003; GG vs. AG + AA: OR = 1.570, 95% CI = 1.160−2.123, P = 0.003), but no statistically significant differences were observed between cases and controls for IL-10 −819C/T and IL-10 −592C/A polymorphisms ( P > 0.05). In conclusion, this meta-analysis suggested that the IL-10 −1082GG genotype was associated with increased susceptibility for chronic HCV infection.
Archives of Virology – Springer Journals
Published: Nov 1, 2010
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