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Toshiki Mori, Yoshio Anazawa, Megumi Iiizumi, S. Fukuda, Yusuke Nakamura, H. Arakawa (2002)
Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53Oncogene, 21
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Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequencesThe EMBO Journal, 18
Inke Schaper, G. Marcuzzi, S. Weissenborn, H. Kasper, V. Dries, N. Smyth, P. Fuchs, H. Pfister (2005)
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B. Akgül, James Cooke, A. Storey (2006)
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Henrike Pajunk, Cornelia May, Herbert Pfister, P. Fuchs (1997)
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Interferon Regulatory Factor 5 Represses Expression of the Epstein-Barr Virus Oncoprotein LMP1: Braking of the IRF7/LMP1 Regulatory CircuitJournal of Virology, 79
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Papillomaviruses
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Takashi Fujita, J. Sakakibara, Y. Sudo, Masaaki Miyamoto, Y. Kimura, Tadatsugu Taniguchi (1988)
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Human papillomavirus type 8 (HPV8) poses a high risk for malignant conversion of skin lesions in patients with Epidermodysplasia verruciformis (Ev). Its oncogene promoter P 175 contains the conserved sequence motifs CCAAC, M29, and an A/T-rich region, which are common in many Ev-associated viruses. In human keratinocytes P 175 shows very weak activity. We used the M29 sequence as bait in a yeast-one-hybrid screen of a HaCaT cDNA library to identify interacting proteins regulating P 175 . We report the identification of a cDNA encoding the interferon regulatory factor IRF5.2. In band shift assays the physical interaction of IRF5.2 and M29 was confirmed, and also its binding to the negative regulatory element (NRE) of HPV8 could be demonstrated. In transient reporter gene assays, overexpressed IRF5.2 acts as a transcriptional repressor of HPV8 and the Ev-associated HPV types 5, 14, and 25. These results indicate that the cellular transcription factor IRF5.2 is a general transcription repressor of Ev-associated HPV.
Archives of Virology – Springer Journals
Published: Dec 1, 2006
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