Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection

Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection Rabies virus infection is a major public health concern because of its wide host-interference spectrum and nearly 100 % lethality. However, the interactions between host and virus remain unclear. To decipher the authentic response in the central nervous system after rabies virus infection, a dynamic analysis of brain proteome alteration was performed. In this study, 104 significantly differentially expressed proteins were identified, and intermediate filament, interferon-inducible GTPases, and leucine-rich repeat-containing protein 16C were the three outstanding groups among these proteins. Interferon-inducible GTPases were prominent because of their strong upregulation. Moreover, quantitative real-time PCR showed distinct upregulation of interferon-inducible GTPases at the level of transcription. Several studies have shown that interferon-inducible GTPases are involved in many biological processes, such as viral infection, endoplasmic reticulum stress response, and autophagy. These findings indicate that interferon-inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Loading next page...
 
/lp/springer_journal/interferon-inducible-gtpase-a-novel-viral-response-protein-involved-in-kD86WwTcfx
Publisher
Springer Vienna
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-016-2795-x
Publisher site
See Article on Publisher Site

References

  • Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
    Bantscheff, M; Lemeer, S; Savitski, MM; Kuster, B
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway
    Liu, Z; Zhang, HM; Yuan, J; Ye, X; Taylor, GA; Yang, D
  • The interferon-inducible GTPases
    Martens, S; Howard, J
  • Viral proteomics
    Maxwell, KL; Frappier, L
  • GTPase activating proteins: structural and functional insights 18 years after discovery
    Scheffzek, K; Ahmadian, MR
  • IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens
    Taylor, GA
  • Global gene expression changes in BV2 microglial cell line during rabies virus infection
    Zhao, P; Yang, Y; Feng, H; Zhao, L; Qin, J; Zhang, T; Wang, H; Yang, S; Xia, X

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial