Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection

Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection Rabies virus infection is a major public health concern because of its wide host-interference spectrum and nearly 100 % lethality. However, the interactions between host and virus remain unclear. To decipher the authentic response in the central nervous system after rabies virus infection, a dynamic analysis of brain proteome alteration was performed. In this study, 104 significantly differentially expressed proteins were identified, and intermediate filament, interferon-inducible GTPases, and leucine-rich repeat-containing protein 16C were the three outstanding groups among these proteins. Interferon-inducible GTPases were prominent because of their strong upregulation. Moreover, quantitative real-time PCR showed distinct upregulation of interferon-inducible GTPases at the level of transcription. Several studies have shown that interferon-inducible GTPases are involved in many biological processes, such as viral infection, endoplasmic reticulum stress response, and autophagy. These findings indicate that interferon-inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals
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Publisher
Springer Vienna
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-016-2795-x
Publisher site
See Article on Publisher Site

Abstract

Rabies virus infection is a major public health concern because of its wide host-interference spectrum and nearly 100 % lethality. However, the interactions between host and virus remain unclear. To decipher the authentic response in the central nervous system after rabies virus infection, a dynamic analysis of brain proteome alteration was performed. In this study, 104 significantly differentially expressed proteins were identified, and intermediate filament, interferon-inducible GTPases, and leucine-rich repeat-containing protein 16C were the three outstanding groups among these proteins. Interferon-inducible GTPases were prominent because of their strong upregulation. Moreover, quantitative real-time PCR showed distinct upregulation of interferon-inducible GTPases at the level of transcription. Several studies have shown that interferon-inducible GTPases are involved in many biological processes, such as viral infection, endoplasmic reticulum stress response, and autophagy. These findings indicate that interferon-inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2016

References

  • Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
    Bantscheff, M; Lemeer, S; Savitski, MM; Kuster, B
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway
    Liu, Z; Zhang, HM; Yuan, J; Ye, X; Taylor, GA; Yang, D
  • The interferon-inducible GTPases
    Martens, S; Howard, J
  • Viral proteomics
    Maxwell, KL; Frappier, L
  • GTPase activating proteins: structural and functional insights 18 years after discovery
    Scheffzek, K; Ahmadian, MR
  • IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens
    Taylor, GA
  • Global gene expression changes in BV2 microglial cell line during rabies virus infection
    Zhao, P; Yang, Y; Feng, H; Zhao, L; Qin, J; Zhang, T; Wang, H; Yang, S; Xia, X

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