Interferon-alpha/sunitinib Reactions 1680, p186 - 2 Dec 2017 Thrombotic microangiopathy: 2 case reports In a study of 117 cancer patients, a 57-year-old man and a 74-year-old woman, developed thrombotic microangiopathy at the end of one year of interferon α therapy for chronic myeloid leukaemia and at the end of six months of sunitinib [sunitinib malate] therapy for gastric mesothelioma, respectively [routes, dosages and outcomes not stated]. In both the patients. light microscopy showed diffuse and severe endothelial damage with double contours and occlusion of capillary lumen, while electron microscopy of the glomerular capillary wall showed expansion of the subendothelial space by electron-lucent debris. Author comment: "The present study observed three biopsy-confirmed rare cases: [thrombotic microangiopathy] in a patient with [chronic myeloid leukaemia] taking interfon- [alpha] and in a patient with gastric mesothelioma taking sunitinib malate." Wang T, et al. Acute kidney injury in cancer patients and impedance cardiography- assisted renal replacement therapy: Experience from the onconephrology unit of a Chinese tertiary hospital. Experimental and Therapeutic Medicine 14: 5671-5677, No. 6, Dec 2017. Available from: URL: - China 803285335 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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