Interferon β 1a

Interferon β 1a Reactions 1680, p184 - 2 Dec 2017 Psoriasis flare and Koebner phenomenon along abdominal injection site: case report A 26-year-old woman developed psoriasis flare and Koebner phenomenon along abdominal injection site during treatment with interferon β 1a [dosage and duration of treatment to reaction onset not stated]. The woman had a history of psoriasis. Subsequently, she was diagnosed with relapsing-remitting multiple sclerosis (RRMS). As a result, she received SC injection of interferon β 1a as first-line treatment for RRMS. However, four months after the initiation, the woman’s interferon β 1a therapy was switched to oral dimethyl fumarate due to the psoriasis flare with plaques in the upper and lower extremities. Additionally, she developed Koebner phenomenon at abdominal injection sites. Within 14 months of the initiation of dimethyl fumarate, a complete remission in her psoriatic eruptions was observed along with a residual discolouration in former Koebner-positive sites. From the last 3 years, she had been receiving dimethyl fumarate without any further relapse in multiple sclerosis. Author comment: "Interferon-induced psoriasis flare in a multiple sclerosis case remits with dimethyl fumarate." "Interferon was discontinued 4 months later, following a dramatic psoriasis flare with plaques in upper and lower extremities and manifestation of Koebner phenomenon along abdominal injection sites." Tsivgoulis G, et al. Teaching Neuro Images: Interferon-induced psoriasis flare in a multiple sclerosis case remits with dimethyl fumarate. Neurology 89: e188-e189, No. 15, 10 Oct 2017. Available from: URL: http://doi.org/10.1212/ WNL.0000000000004501 - Greece 803284862 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Interferon β 1a

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39115-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p184 - 2 Dec 2017 Psoriasis flare and Koebner phenomenon along abdominal injection site: case report A 26-year-old woman developed psoriasis flare and Koebner phenomenon along abdominal injection site during treatment with interferon β 1a [dosage and duration of treatment to reaction onset not stated]. The woman had a history of psoriasis. Subsequently, she was diagnosed with relapsing-remitting multiple sclerosis (RRMS). As a result, she received SC injection of interferon β 1a as first-line treatment for RRMS. However, four months after the initiation, the woman’s interferon β 1a therapy was switched to oral dimethyl fumarate due to the psoriasis flare with plaques in the upper and lower extremities. Additionally, she developed Koebner phenomenon at abdominal injection sites. Within 14 months of the initiation of dimethyl fumarate, a complete remission in her psoriatic eruptions was observed along with a residual discolouration in former Koebner-positive sites. From the last 3 years, she had been receiving dimethyl fumarate without any further relapse in multiple sclerosis. Author comment: "Interferon-induced psoriasis flare in a multiple sclerosis case remits with dimethyl fumarate." "Interferon was discontinued 4 months later, following a dramatic psoriasis flare with plaques in upper and lower extremities and manifestation of Koebner phenomenon along abdominal injection sites." Tsivgoulis G, et al. Teaching Neuro Images: Interferon-induced psoriasis flare in a multiple sclerosis case remits with dimethyl fumarate. Neurology 89: e188-e189, No. 15, 10 Oct 2017. Available from: URL: http://doi.org/10.1212/ WNL.0000000000004501 - Greece 803284862 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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