J. Membrane Biol. 178, 163–173 (2000) The Journal of DOI: 10.1007/s002320010032 Membrane Biology © Springer-Verlag New York Inc. 2000 Topical Review M. Oheim*, W. Stu ¨ hmer Max Planck-Institute for Experimental Medicine, Molecular Biology of Neuronal Signals, Hermann-Rein Str. 3, D-37075 Go ¨ ttingen, Germany Received: 25 May 2000 Introduction bringing studies of individual synaptic vesicle-dynamics into reach (Zenisek et al., 2000). Various aspects of the vesicle cycle have been re- Neurones and neuroendocrine cells release transmitters viewed recently. These include the molecules orches- and hormones by exocytosis of secretory vesicles or trating the vesicle cycle (Bajjalieh & Scheller, 1995; granules. To become available for release, these mem- Su ¨ dhof, 1995; Hanson et al., 1997; Burger & Schaefer, brane-delimited organelles move from the cytoplasm to 1998; Fernandez-Chacon & Su ¨ dhof, 1999; Bajjalieh, the plasma membrane where they get immobilized. 2+ 1999), the role of intracellular free calcium ([Ca ] ) Upon stimulation, secretory organelles at the periphery (Su ¨ dhof & Rizo, 1996; Zucker, 1996; Neher, 1998; of the cell fuse with the cell’s surface, where their cargo Zucker, 1999), the behavior and fate of the fusion pore is liberated. After exocytosis, the vesicle’s membrane is (Betz
The Journal of Membrane Biology – Springer Journals
Published: Dec 1, 2000
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