Interaction of mutant genes Fgf5 go-Y , we, and wal changes the duration of hair growth cycles in mice

Interaction of mutant genes Fgf5 go-Y , we, and wal changes the duration of hair growth cycles... Mutant gene wallhaarig (wa) was acting as a modifier of the mutant gene waved alopecia (wal), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted to a study of mutant gene angora-Y (Fgf5 go-Y ), which had extended anagen stage of the first and second generations hair growth cycles in triple heterozygotes (Fgf5 go-Y /Fgf5 go-Y we/we wal/wal). First generation guard hair in triple homozygotes had their anagen stage 4 days longer than the same stage in double homozygotes (+/+ we/we wal/wal). Hair loss started at a catagen stage in double homozygotes, while it started in triple homozygotes at the end of the same stage or even in a telogen. Such mutant gene interaction in hair follicle morphogenesis led to a partial recovery of a body hair coat in triple homozygotes. Russian Journal of Developmental Biology Springer Journals

Interaction of mutant genes Fgf5 go-Y , we, and wal changes the duration of hair growth cycles in mice

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SP MAIK Nauka/Interperiodica
Copyright © 2012 by Pleiades Publishing, Ltd.
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
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