J Endocrinol Invest (2018) 41:421–429 https://doi.org/10.1007/s40618-017-0760-5 ORIGINAL ARTICLE Interaction between gender and uric acid on hemoglobin A1c in community‑dwelling persons 1,2 1,2 2 1 2 R. Kawamoto · D. Ninomiya · Y. Kasai · K. Senzaki · T. Kusunoki · 2 1 N. Ohtsuka · T. Kumagi Received: 18 November 2016 / Accepted: 28 August 2017 / Published online: 25 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract antidiabetic medication (β = 0.428, p < 0.001) and eGFR Introduction Higher glycated hemoglobin (Hb) (HbA1c) (β = 0.112, p = 0.016) were significantly and negatively is significantly associated with an increased risk of cardio - associated with HbA1c, and in women, SUA (β = 0.101, vascular disease (CVD). Serum uric acid (SUA) levels are p = 0.002) with prevalence of antidiabetic medication associated with glucose intolerance and type 2 diabetes. (β = 0.458, p < 0.001) were significantly and positively Whether gender-specific differences regarding the relation - associated with HbA1c. Moreover, the interaction between ship between SUA levels and HbA1c exist is unknown. gender and SUA (β = 0.445, p < 0.001) as well as gen- Aim We recruited 1636 (men, 696 aged of 70 ± 10 years; der (β = −0.465, p < 0.001), prevalence of antidiabetic women, 940 aged of 70 ± 9 years) participants and enrolled medication (β = 0.444, p < 0.001), eGFR (β = 0.074, CKDEPI in
Journal of Endocrinological Investigation – Springer Journals
Published: Sep 25, 2017
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