Analysis of radiosensitivity of double mutants in the yeast Saccharomyces cerevisiae revealed that checkpoint genes RAD9, RAD17, RAD24, and RAD53 along with genes CDC28 and NET1 belong to one epistasis group designated the RAD9 group. The use of srm mutations allowed the demonstration of a branched RAD9-dependent pathway of cell radioresistance. Mutation cdc28-srm is hypostatic to rad9Δ, rad17Δ, and rad24Δ being additive with rad53. Mutation net1-srm is hypostatic to rad9Δ and rad53 but additively enhance the effects of mutations rad17Δ and rad24Δ. Gene SRM12/HFI1 is not a member of the RAD9 group. Mutation in gene hfi1-srm manifests the additive effect on mutations rad24Δ and rad9Δ. The analyzed genes can also participate in minor mechanisms of radioresistance that are relatively independent of the above RAD9-dependent mechanism.
Russian Journal of Genetics – Springer Journals
Published: Aug 22, 2008
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera