Objectives To assess inter-sonographer reproducibility of ultrasound attenuation coefficient (AC), backscatter coefficient (BSC) and shear wave speed (SWS) in adults with known/suspected non-alcoholic fatty liver disease (NAFLD). Methods The institutional review board approved this HIPAA-compliant prospective study; informed consent was obtained. Participants with known/suspected NAFLD were recruited and underwent same-day liver examinations with a clinical scanner. Each participant was scanned by two of the six trained sonographers. Each sonographer performed multiple data acquisitions in the right liver lobe using a lateral intercostal approach. A data acquisition was a single operator button press that recorded a B- mode image, radio-frequency data, and the SWS value. AC and BSC were calculated from the radio-frequency data using the reference phantom method. SWS was calculated automatically using product software. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wCV) were calculated for applicable metrics. Results Sixty-one participants were recruited. Inter-sonographer ICC was 0.86 (95% confidence interval: 0.77–0.92) for AC and 0.87 (0.78–0.92) for log-transformed BSC (logBSC =10log BSC) using one acquisition per sonographer. ICC was 0.88 (0.80– 0.93) for both AC and logBSC averaging 5 acquisitions. ICC for SWS was 0.57 (0.29–0.74) using one acquisition per sonog- rapher, and 0.84 (0.66–0.93) using 10
European Radiology – Springer Journals
Published: Jun 4, 2018
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