J. Membrane Biol. 165, 191–199 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review K. Vuori La Jolla Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA Received: 12 November 1997/Revised: 24 April 1998 Introduction are major sites of signal transduction is supported by the identification of multiple signaling proteins at these sites. This review focuses on recent evidence concerning the Adhesive interactions between cells and the surrounding role of tyrosine phosphorylation events in integrin- meshwork of extracellular matrix (ECM) proteins plays a mediated signaling. For a more comprehensive discus- vital role in numerous complex biological processes that sion on integrin signaling, the reader is referred to sev- include cell migration, cell proliferation and differentia- eral recent excellent reviews [9, 21, 105, 123]. tion, cell survival, blood clotting and inflammatory re- sponses. While the overall phenomenology of ECM ef- fects on cell behavior is relatively well known, the bio- Focal Adhesions are Sites for Integrin Signaling chemical and molecular bases for these effects have remained elusive. It is clear that many of the interactions The focal adhesions of tissue culture cells provide a con- between cells and
The Journal of Membrane Biology – Springer Journals
Published: Oct 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera