Integrin Signaling: Tyrosine Phosphorylation Events in Focal Adhesions

Integrin Signaling: Tyrosine Phosphorylation Events in Focal Adhesions J. Membrane Biol. 165, 191–199 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review K. Vuori La Jolla Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA Received: 12 November 1997/Revised: 24 April 1998 Introduction are major sites of signal transduction is supported by the identification of multiple signaling proteins at these sites. This review focuses on recent evidence concerning the Adhesive interactions between cells and the surrounding role of tyrosine phosphorylation events in integrin- meshwork of extracellular matrix (ECM) proteins plays a mediated signaling. For a more comprehensive discus- vital role in numerous complex biological processes that sion on integrin signaling, the reader is referred to sev- include cell migration, cell proliferation and differentia- eral recent excellent reviews [9, 21, 105, 123]. tion, cell survival, blood clotting and inflammatory re- sponses. While the overall phenomenology of ECM ef- fects on cell behavior is relatively well known, the bio- Focal Adhesions are Sites for Integrin Signaling chemical and molecular bases for these effects have remained elusive. It is clear that many of the interactions The focal adhesions of tissue culture cells provide a con- between cells and The Journal of Membrane Biology Springer Journals

Integrin Signaling: Tyrosine Phosphorylation Events in Focal Adhesions

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Copyright © Inc. by 1998 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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