Integrating mouse anatomy and pathology ontologies into a phenotyping database: Tools for data capture and training

Integrating mouse anatomy and pathology ontologies into a phenotyping database: Tools for data... The Mouse Disease Information System (MoDIS) is a data capture system for pathology data from laboratory mice designed to support phenotyping studies. The system integrates the mouse anatomy (MA) and mouse pathology (MPATH) ontologies into a Microsoft Access database facilitating the coding of organ, tissue, and disease process to recognized semantic standards. Grading of disease severity provides scores for all lesions that can then be used for quantitative trait locus (QTL) analyses and haplotype association gene mapping. Direct linkage to the Pathbase online database provides reference definitions for disease terms and access to photomicrographic images of similar diagnoses in other mutant mice. MoDIS is an open source and freely available program ( http://research.jax.org/faculty/sundberg/index.html ). This provides a valuable tool for setting up a mouse pathology phenotyping program. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Integrating mouse anatomy and pathology ontologies into a phenotyping database: Tools for data capture and training

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Publisher
Springer Journals
Copyright
Copyright © 2008 by The Authors
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-008-9123-z
Publisher site
See Article on Publisher Site

Abstract

The Mouse Disease Information System (MoDIS) is a data capture system for pathology data from laboratory mice designed to support phenotyping studies. The system integrates the mouse anatomy (MA) and mouse pathology (MPATH) ontologies into a Microsoft Access database facilitating the coding of organ, tissue, and disease process to recognized semantic standards. Grading of disease severity provides scores for all lesions that can then be used for quantitative trait locus (QTL) analyses and haplotype association gene mapping. Direct linkage to the Pathbase online database provides reference definitions for disease terms and access to photomicrographic images of similar diagnoses in other mutant mice. MoDIS is an open source and freely available program ( http://research.jax.org/faculty/sundberg/index.html ). This provides a valuable tool for setting up a mouse pathology phenotyping program.

Journal

Mammalian GenomeSpringer Journals

Published: Sep 17, 2008

References

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