Curr Stem Cell Rep (2017) 3:253–259 DOI 10.1007/s40778-017-0097-1 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer. Part 1: Biological Facts and Studies in Drug Resistance 1,2,3,4,5 6,7 8,9 Aaron Goldman & Mohammad Kohandel & Jean Clairambault Published online: 3 August 2017 Springer International Publishing AG 2017 Abstract explain the role of CSC and other cancer cells in the context Purpose of Review Successful, durable cancer treatment is of the entire ecosystem. limited by drug resistance. Cancer stem cells (CSC) comprise Recent Findings Starting from biological evidence, we review (typically) a rare tumor subpopulation that contributes both the current state of cancer research from the perspective of the intrinsic drug resistance and tumor re-initiation after therapy. single-cell level, BThe cancer cell,^ its intrinsic physiopathology Emerging evidence suggests that drug resistance is more com- and its response to drug exposure. We discuss insufficiencies of plex than this single-cell level might suggest, and is likely this level of observation, in particular, the unaccounted for resis- governed by dynamics encompassing the entire tumor popu- tance to targeted therapies, and show why it is necessary to con- lation. Here,
Current Stem Cell Reports – Springer Journals
Published: Aug 3, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera