Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer. Part 1: Biological Facts and Studies in Drug Resistance

Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer.... Curr Stem Cell Rep (2017) 3:253–259 DOI 10.1007/s40778-017-0097-1 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer. Part 1: Biological Facts and Studies in Drug Resistance 1,2,3,4,5 6,7 8,9 Aaron Goldman & Mohammad Kohandel & Jean Clairambault Published online: 3 August 2017 Springer International Publishing AG 2017 Abstract explain the role of CSC and other cancer cells in the context Purpose of Review Successful, durable cancer treatment is of the entire ecosystem. limited by drug resistance. Cancer stem cells (CSC) comprise Recent Findings Starting from biological evidence, we review (typically) a rare tumor subpopulation that contributes both the current state of cancer research from the perspective of the intrinsic drug resistance and tumor re-initiation after therapy. single-cell level, BThe cancer cell,^ its intrinsic physiopathology Emerging evidence suggests that drug resistance is more com- and its response to drug exposure. We discuss insufficiencies of plex than this single-cell level might suggest, and is likely this level of observation, in particular, the unaccounted for resis- governed by dynamics encompassing the entire tumor popu- tance to targeted therapies, and show why it is necessary to con- lation. Here, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Stem Cell Reports Springer Journals

Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer. Part 1: Biological Facts and Studies in Drug Resistance

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Life Sciences; Cell Biology; Stem Cells
eISSN
2198-7866
D.O.I.
10.1007/s40778-017-0097-1
Publisher site
See Article on Publisher Site

Abstract

Curr Stem Cell Rep (2017) 3:253–259 DOI 10.1007/s40778-017-0097-1 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer. Part 1: Biological Facts and Studies in Drug Resistance 1,2,3,4,5 6,7 8,9 Aaron Goldman & Mohammad Kohandel & Jean Clairambault Published online: 3 August 2017 Springer International Publishing AG 2017 Abstract explain the role of CSC and other cancer cells in the context Purpose of Review Successful, durable cancer treatment is of the entire ecosystem. limited by drug resistance. Cancer stem cells (CSC) comprise Recent Findings Starting from biological evidence, we review (typically) a rare tumor subpopulation that contributes both the current state of cancer research from the perspective of the intrinsic drug resistance and tumor re-initiation after therapy. single-cell level, BThe cancer cell,^ its intrinsic physiopathology Emerging evidence suggests that drug resistance is more com- and its response to drug exposure. We discuss insufficiencies of plex than this single-cell level might suggest, and is likely this level of observation, in particular, the unaccounted for resis- governed by dynamics encompassing the entire tumor popu- tance to targeted therapies, and show why it is necessary to con- lation. Here,

Journal

Current Stem Cell ReportsSpringer Journals

Published: Aug 3, 2017

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