Curr Stem Cell Rep (2017) 3:248–252 DOI 10.1007/s40778-017-0096-2 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) 1 1 Hanna L. Sladitschek & Pierre A. Neveu Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication . . . Abstract Keywords Stem cells Embryonic stem cells Modeling . . . Purpose of Review Stem cells have to balance self-renewal Single-cellheterogeneity Differentiation Self-organization and differentiation. The dynamic nature of these fate decisions Morphogenesis has made stem cell study by traditional methods particularly challenging. Here we highlight recent advances in the field that draw on combining quantitative experiments and model- Introduction ing to illuminate the biology of stem cells both in vitro and in vivo. Stem cells possess the dual ability to either self-renew or dif- Recent Findings Recent studies have shown that seemingly ferentiate. This fate decision is dynamically controlled to cre- complex processes such as the fate decision-making of stem ate and maintain a functional tissue derived from a small num- cells or the self-organization of developing tissues obey re- ber of stem cells. Identifying and studying critical factors that markably simple mathematical models. Negative feedback influence stem cell behavior requires monitoring the
Current Stem Cell Reports – Springer Journals
Published: Jul 10, 2017
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