Insulin-aspart/insulin-glargine Reactions 1680, p182 - 2 Dec 2017 Ventricular arrhythmia secondary to electrolyte disturbance and Brugada syndrome : case report A 16-year-old boy died due to ventricular arrhythmia secondary to electrolyte disturbance and Brugada syndrome following treatment with insulin aspart and insulin glargine. The boy found dead on his bed in the morning. He had been diagnosed with type 1 diabetes mellitus at the age of 15 years. He had been receiving insulin aspart injection approximately 12 units thrice daily at meal depending upon existing blood sugar level and carbohydrate load and insulin glargine 30 units injection at bed time. On the evening prior to his death, he had full meal and received insulins and went to bed as usual. In the next morning, he was found dead lying face down on his bed. An autopsy, did not provide exact cause of death. Genetic analysis of autopsy DNA showed a missense mutation in the GPD1L gene. His father also have the same mutation with QT prolongation. The findings suggested that the probable cause of death was ventricular arrhythmia secondary to electrolyte disturbance and Brugada syndrome. Author comment: "The patient may have died from a ventricular arrhythmia, secondary to occult Brugada syndrome, triggered by a full stomach and insulin." Skinner JR, et al. Diabetic dead-in-bed syndrome: A possible link to a cardiac ion channelopathy. Case Reports in Medicine 2014: 2014. Available from: URL: http:// - New Zealand 803284634 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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