Curr Diab Rep (2017) 17: 120 https://doi.org/10.1007/s11892-017-0955-3 MACROVASCULAR COMPLICATIONS IN DIABETES (VR ARODA AND A GETANEH, SECTION EDITORS) Insulin and Its Cardiovascular Effects: What Is the Current Evidence? 1 1 1 Sahana Pai Dongerkery & Pamela R. Schroeder & Mansur E. Shomali Published online: 23 October 2017 Springer Science+Business Media, LLC 2017 Abstract hyperinsulinemia as a major factor for poor cardiovascular Purpose of Review In this article, we examine the nature of outcomes. Additional studies link the anabolic effects of ther- the complex relationship between insulin and cardiovascular apeutic insulin to weight gain, along with hypoglycemia, disease. With metabolic abnormalities comes increased risk which may further aggravate cardiovascular risk in this popu- for cardiovascular complications. We discuss the key factors lation. Though good glycemic control has been shown to im- implicated in development and progression of cardiovascular prove microvascular risks in type 1 and type 2 diabetes, what disease, its relationship to insulin therapy, and what can be are the known cardiovascular effects of insulin therapy? The learned from large, recent cardiovascular outcome studies. ORIGIN trial suggests at least a neutral effect of the basal Recent Findings Preclinical studies suggest that insulin has insulin glargine on cardiovascular outcomes. Recent
Current Diabetes Reports – Springer Journals
Published: Oct 23, 2017
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