Enhancers can activate a promoter located as far as several hundred kilobases away, which is specific for transcription regulation in higher eukaryotes. Notwithstanding the vast information accumulated on transcription regulation at various levels, the mechanism of long-distance enhancer–promoter interactions is still obscure. Modern views of insulators as elements modulating enhancer–promoter interactions are reviewed.
Russian Journal of Genetics – Springer Journals
Published: Oct 8, 2004
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