Curr Epidemiol Rep (2017) 4:281–287 https://doi.org/10.1007/s40471-017-0120-1 PHARMACOEPIDEMIOLOGY (S TOH, SECTION EDITOR) Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate? Sonja A. Swanson Published online: 17 October 2017 The Author(s) 2017. This article is an open access publication Abstract or explored via sensitivity analyses, and that this serves as a Purpose of review When leveraging observational data to es- framework for scientific discourse regarding IV and non-IV re- timate treatment effects, it is useful to explicitly specify the sultsemulatingpotentiallydifferenttrialswithdifferenttradeoffs. “target trial” the investigators aspire to emulate. One concern . . is whether a proposed analysis plan can address the realities of Keywords Instrumental variable Target trial the differences between the available non-randomized obser- Pharmacoepidemiology vational study and the target trial. When large or unknown sources of unmeasured confounding are suspected, investiga- tors might consider turning to instrumental variable (IV) Introduction methods. Of course, the interpretation and appropriateness of IV analyses need to be considered carefully. The purpose of When leveraging observational data to estimate treatment ef- this review is to summarize recent methodologic advance- fects, it is useful to explicitly specify the “target trial” the ments in how epidemiologists weigh the validity of an IV investigators aspire
Current Epidemiology Reports – Springer Journals
Published: Oct 17, 2017
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