Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate?

Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate? Curr Epidemiol Rep (2017) 4:281–287 https://doi.org/10.1007/s40471-017-0120-1 PHARMACOEPIDEMIOLOGY (S TOH, SECTION EDITOR) Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate? Sonja A. Swanson Published online: 17 October 2017 The Author(s) 2017. This article is an open access publication Abstract or explored via sensitivity analyses, and that this serves as a Purpose of review When leveraging observational data to es- framework for scientific discourse regarding IV and non-IV re- timate treatment effects, it is useful to explicitly specify the sultsemulatingpotentiallydifferenttrialswithdifferenttradeoffs. “target trial” the investigators aspire to emulate. One concern . . is whether a proposed analysis plan can address the realities of Keywords Instrumental variable Target trial the differences between the available non-randomized obser- Pharmacoepidemiology vational study and the target trial. When large or unknown sources of unmeasured confounding are suspected, investiga- tors might consider turning to instrumental variable (IV) Introduction methods. Of course, the interpretation and appropriateness of IV analyses need to be considered carefully. The purpose of When leveraging observational data to estimate treatment ef- this review is to summarize recent methodologic advance- fects, it is useful to explicitly specify the “target trial” the ments in how epidemiologists weigh the validity of an IV investigators aspire http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Epidemiology Reports Springer Journals

Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate?

Loading next page...
 
/lp/springer_journal/instrumental-variable-analyses-in-pharmacoepidemiology-what-target-rZVOJR3vIL
Publisher
Springer Journals
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Epidemiology
eISSN
2196-2995
D.O.I.
10.1007/s40471-017-0120-1
Publisher site
See Article on Publisher Site

Abstract

Curr Epidemiol Rep (2017) 4:281–287 https://doi.org/10.1007/s40471-017-0120-1 PHARMACOEPIDEMIOLOGY (S TOH, SECTION EDITOR) Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate? Sonja A. Swanson Published online: 17 October 2017 The Author(s) 2017. This article is an open access publication Abstract or explored via sensitivity analyses, and that this serves as a Purpose of review When leveraging observational data to es- framework for scientific discourse regarding IV and non-IV re- timate treatment effects, it is useful to explicitly specify the sultsemulatingpotentiallydifferenttrialswithdifferenttradeoffs. “target trial” the investigators aspire to emulate. One concern . . is whether a proposed analysis plan can address the realities of Keywords Instrumental variable Target trial the differences between the available non-randomized obser- Pharmacoepidemiology vational study and the target trial. When large or unknown sources of unmeasured confounding are suspected, investiga- tors might consider turning to instrumental variable (IV) Introduction methods. Of course, the interpretation and appropriateness of IV analyses need to be considered carefully. The purpose of When leveraging observational data to estimate treatment ef- this review is to summarize recent methodologic advance- fects, it is useful to explicitly specify the “target trial” the ments in how epidemiologists weigh the validity of an IV investigators aspire

Journal

Current Epidemiology ReportsSpringer Journals

Published: Oct 17, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off