J. Membrane Biol. 180, 187–194 (2001) The Journal of DOI: 10.1007/s002320010069 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review 1 2 S. Cockcroft , M.A. De Matteis Department of Physiology, Rockefeller Building, University St., University College London, London WC1E 6JJ, UK Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy 66030 Received: 22 May 2000/Revised: 1 September 2000 Introduction in PC12 cells  and from genetic studies in Saccha- romyces cerevisiae where the secretory mutant, Sec14 showed defects in exit of secretory vesicles from the Phosphoinositides have been in the limelight for over Golgi and where the gene product responsible for these two decades following their identification as sources of defects was identified as the yeast phosphatidylinositol the second messengers, diacylglycerol, inositol(1,4,5) transfer protein (PITP) . Subsequent studies led to the trisphosphate (IP ) and phosphatidylinositol(3,4,5) 3 identification of PITP, the small GTPase ARF, phospha- trisphosphate (PtdIns(3,4,5)P ). The last 10 years have tidylinositol 4-kinases (PI4K), phosphatidylinositol witnessed an explosion of experimental results that dem- 4-phosphate 5-kinase (PIP5K) and PIP phosphatases as onstrate that inositol lipids themselves should be consid- regulators of membrane trafficking along the exocytic ered as second messengers
The Journal of Membrane Biology – Springer Journals
Published: Mar 19, 2014
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