Innate Immunity and Mobilization of Hematopoietic Stem Cells

Innate Immunity and Mobilization of Hematopoietic Stem Cells Curr Stem Cell Rep (2017) 3:172–180 DOI 10.1007/s40778-017-0087-3 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) 1,2 1,2 Mateusz Adamiak & Mariusz Z. Ratajczak Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication . . Abstract Keywords Complement cascade Hematopoietic stem cells . . Purpose of Review Several mechanisms have been postulated Stem cell mobilization HO-1 iNOS to orchestrate mobilization of hematopoietic stem/progenitor cells (HSPCs), and still more work is needed to better under- stand this process and to gain better mechanistic insight. Recent Findings Evidence accumulated that mobilization of Introduction HSPCs is a part of innate immunity response to tissue organ injury, stress, and infection. This evolutionary ancient process The alpha-chemokine stromal derived factor-1 (SDF-1)–C-X- is orchestrated by granulocytes and monocytes that trigger C chemokine receptor type 4 (CXCR4) receptor and vascular activation of complement cascade and the coagulation adhesion molecule-1 (VCAM-1)–very late antigen-4 (VLA-4) cascade. integrin receptor axes play important roles in retention of he- Summary We will present data from our laboratory that initi- matopoietic stem/progenitor cells (HSPCs) in bone marrow ation of complement cascade activation and subsequently ac- (BM) niches [1, 2]. However, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Stem Cell Reports Springer Journals

Innate Immunity and Mobilization of Hematopoietic Stem Cells

Loading next page...
 
/lp/springer_journal/innate-immunity-and-mobilization-of-hematopoietic-stem-cells-iwFg0sq2FY
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by The Author(s)
Subject
Life Sciences; Cell Biology; Stem Cells
eISSN
2198-7866
D.O.I.
10.1007/s40778-017-0087-3
Publisher site
See Article on Publisher Site

Abstract

Curr Stem Cell Rep (2017) 3:172–180 DOI 10.1007/s40778-017-0087-3 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) 1,2 1,2 Mateusz Adamiak & Mariusz Z. Ratajczak Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication . . Abstract Keywords Complement cascade Hematopoietic stem cells . . Purpose of Review Several mechanisms have been postulated Stem cell mobilization HO-1 iNOS to orchestrate mobilization of hematopoietic stem/progenitor cells (HSPCs), and still more work is needed to better under- stand this process and to gain better mechanistic insight. Recent Findings Evidence accumulated that mobilization of Introduction HSPCs is a part of innate immunity response to tissue organ injury, stress, and infection. This evolutionary ancient process The alpha-chemokine stromal derived factor-1 (SDF-1)–C-X- is orchestrated by granulocytes and monocytes that trigger C chemokine receptor type 4 (CXCR4) receptor and vascular activation of complement cascade and the coagulation adhesion molecule-1 (VCAM-1)–very late antigen-4 (VLA-4) cascade. integrin receptor axes play important roles in retention of he- Summary We will present data from our laboratory that initi- matopoietic stem/progenitor cells (HSPCs) in bone marrow ation of complement cascade activation and subsequently ac- (BM) niches [1, 2]. However,

Journal

Current Stem Cell ReportsSpringer Journals

Published: Jul 10, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off