Innate Immunity and Mobilization of Hematopoietic Stem Cells

Innate Immunity and Mobilization of Hematopoietic Stem Cells Curr Stem Cell Rep (2017) 3:172–180 DOI 10.1007/s40778-017-0087-3 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) 1,2 1,2 Mateusz Adamiak & Mariusz Z. Ratajczak Published online: 10 July 2017 The Author(s) 2017. This article is an open access publication . . Abstract Keywords Complement cascade Hematopoietic stem cells . . Purpose of Review Several mechanisms have been postulated Stem cell mobilization HO-1 iNOS to orchestrate mobilization of hematopoietic stem/progenitor cells (HSPCs), and still more work is needed to better under- stand this process and to gain better mechanistic insight. Recent Findings Evidence accumulated that mobilization of Introduction HSPCs is a part of innate immunity response to tissue organ injury, stress, and infection. This evolutionary ancient process The alpha-chemokine stromal derived factor-1 (SDF-1)–C-X- is orchestrated by granulocytes and monocytes that trigger C chemokine receptor type 4 (CXCR4) receptor and vascular activation of complement cascade and the coagulation adhesion molecule-1 (VCAM-1)–very late antigen-4 (VLA-4) cascade. integrin receptor axes play important roles in retention of he- Summary We will present data from our laboratory that initi- matopoietic stem/progenitor cells (HSPCs) in bone marrow ation of complement cascade activation and subsequently ac- (BM) niches [1, 2]. However, Current Stem Cell Reports Springer Journals

Innate Immunity and Mobilization of Hematopoietic Stem Cells

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Springer International Publishing
Copyright © 2017 by The Author(s)
Life Sciences; Cell Biology; Stem Cells
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