Innate and adaptive immune responses in patients with pandemic influenza A(H1N1)pdm09

Innate and adaptive immune responses in patients with pandemic influenza A(H1N1)pdm09 Innate and adaptive immune responses play critical roles in the body’s defense against viruses. We investigated the host immune response against the 2009 pandemic H1N1 influenza virus (A(H1N1)pdm09) in patients before and after anti-influenza therapy and found that the numbers of dendritic cells and T cells were significantly reduced compared with those of a healthy control group. In contrast, the frequency of natural killer, γδT and T regulatory (T reg ) cells increased, and the concentrations of plasma interferon (IFN)-α/γ and interleukin (IL-15) were significantly higher than those of the control. Following therapy the frequency of γδT and T reg cells returned to normal; the counts of myeloid dendritic and plasmacytoid dendritic cells were still lower than the control, while the concentrations of IFN-α/γ and IL-15 remained high. We show that infection with A (H1N1)pdm09 was accompanied by changes in peripheral blood lymphocyte subgroups and cytokine profiles, leading to deleterious imbalances in innate and adaptive immunity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Innate and adaptive immune responses in patients with pandemic influenza A(H1N1)pdm09

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Publisher
Springer Vienna
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1692-9
Publisher site
See Article on Publisher Site

Abstract

Innate and adaptive immune responses play critical roles in the body’s defense against viruses. We investigated the host immune response against the 2009 pandemic H1N1 influenza virus (A(H1N1)pdm09) in patients before and after anti-influenza therapy and found that the numbers of dendritic cells and T cells were significantly reduced compared with those of a healthy control group. In contrast, the frequency of natural killer, γδT and T regulatory (T reg ) cells increased, and the concentrations of plasma interferon (IFN)-α/γ and interleukin (IL-15) were significantly higher than those of the control. Following therapy the frequency of γδT and T reg cells returned to normal; the counts of myeloid dendritic and plasmacytoid dendritic cells were still lower than the control, while the concentrations of IFN-α/γ and IL-15 remained high. We show that infection with A (H1N1)pdm09 was accompanied by changes in peripheral blood lymphocyte subgroups and cytokine profiles, leading to deleterious imbalances in innate and adaptive immunity.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 2013

References

  • Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology
    Lambrecht, BN; Hammad, H
  • Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
    Smith, GJ; Vijaykrishna, D; Bahl, J; Lycett, SJ; Worobey, M; Pybus, OG; Ma, SK; Cheung, CL; Raghwani, J; Bhatt, S; Peiris, JS; Guan, Y; Rambaut, A

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