Chemistry of Heterocyclic Compounds 2018, 54(4), 397–399
Submitted December 22, 2017
Accepted after revision February 13, 2018
Sidika Polat-Cakir studied chemistry at the
Middle East Technical University (METU) and
received MSc (1997) degree from the same
university. She earned her PhD degree (2005)
from the Mississippi State University, USA under
the supervision of Prof. Keith T. Mead. Her
research currently involves asymmetric synthesis
of heterocyclic compounds and the synthesis of
phosphorus-containing organic compounds.
Ozdemir Dogan received BSc degree in 1988 and
MSc in 1991 from the Middle East Technical
University (METU). After receiving his PhD in
1995 from the Case Western Reserve University
in Cleveland, OH, USA, he worked as post-
doctoral fellow with Prof. Wolfgang Oppolzer at
the University of Geneva, Switzerland. Since 1997 he
is working as a faculty member at the Chemistry
Department of METU, Ankara. His current interests
are aimed at the development of new chiral catalysts
for asymmetric synthesis of heterocyclic compounds.
diamines, α-amino acids, α-aminophosphonic acids.
addition, they are also useful as chiral ligands for metal-
catalyzed asymmetric synthesis.
After the very first unsub-
stituted aziridine synthesis by Gabriel simply by heating
β-bromoethylamine with KOH in ethanol,
methods for the synthesis of aziridines have been described.
Herein, we only consider examples of asymmetric
synthesis of aziridines published within the last two years.
Aziridine, a three-membered heterocycle containing a
nitrogen atom, is one of the most useful motifs in hetero-
Aziridine unit is found in the structure of
many natural and biologically active compounds, such as
azirinomycin, azicemicin, mitomycin, miraziridine, and other
Aziridine derivatives are also highly valuable
as building blocks of many heterocyclic compounds,
including pyrrolidines, pyrroles, β-lactams, amino alcohols,
This microreview describes recent advances in asymmetric synthesis of aziridine derivatives, which have been
published over the last two years.
Recent progress in asymmetric synthesis
of aziridine derivatives (microreview)
*, Sidika Polat-Cakir
Department of Chemistry, Middle East Technical University,
Ankara 06800, Turkey; e-mail: email@example.com
Department of Chemical Engineering, Canakkale Onsekiz Mart University,
Canakkale 17100, Turkey
One of the most common methods for aziridine synthesis is the
aza-Darzens reaction. Bew et al. reported an elegant application
of this method for the reaction of aldimines with diazo nucleo-
The aza-Darzens reaction using chiral BINOL N-triflylphosphoramides
philes in the presence of a chiral BINOL N-triflylphosphor-
amide Brønsted acid (BA) catalyst.
This methodology was
successfully applied to the synthesis of (+)-chloramphenicol.
Published in Khimiya Geterotsiklicheskikh Soedinenii,
2018, 54(4), 397–399
0009-3122/18/54(4)-0397©2018 Springer Science+Business Media, LLC