Histochem Cell Biol (2017) 148:217–218 DOI 10.1007/s00418-017-1598-9 EDITORIAL In focus in HCB 1 2 Douglas J. Taatjes · Jürgen Roth Accepted: 12 July 2017 / Published online: 19 July 2017 © Springer-Verlag GmbH Germany 2017 New system for monitoring brain neuronal activity thus offers a novel means to monitor and image fluores - cently labeled neurons in deep regions of an awake and in moving rats active rat. One of the great challenges in live animal imaging is the accurate recording of brain neuronal activity in a free-mov- Rotenone effect on peroxisomal dynamics ing animal. Although multiphoton confocal microscopy has been used successfully to image more peripheral regions mediated by microtubules of the brain (Kerr et al. 2005), deeper regions remain inac- cessible. Iijima et al. (2017) have now developed a system Redox biology is an area of great interest for cell biologi- cal responses in health and disease (Little et al. 2017). Two consisting of (1) a single optical fiber for recording neu - ronal activity via eGFP expression (linked to gonadotropin major cellular organelles involved in reactive oxygen spe- cies (ROS) signaling are mitochondria and peroxisomes. releasing hormone), and (2) a newly designed animal cage whereby the floor rotates in response to head movements, Like many intracellular
Histochemistry and Cell Biology – Springer Journals
Published: Jul 19, 2017
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