Inhibition of Glial Na+ and K+ Currents by Tamoxifen

Inhibition of Glial Na+ and K+ Currents by Tamoxifen Tamoxifen (tmx) is a non-steroidal triphenylethylene derivative that is predominantly known as a competitive antagonist at the estrogen receptor and is used in the treatment of breast cancer. Recent studies suggest that tamoxifen is also beneficial in the treatment of brain metastases and primary brain tumors. Tmx accumulates in brain and its concentration can be up to 46-fold higher than in serum. Therefore, astrocytes may be exposed to tmx in vivo. The Journal of Membrane Biology Springer Journals

Inhibition of Glial Na+ and K+ Currents by Tamoxifen

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Copyright © 2001 by Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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